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SGK3 - serum/glucocorticoid regulated kinase family member 3 Gene

Also Known as CISK; SGK2; SGKL

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23678

About SGK3

Cytogenetic location: 8q13.1 Genomic coordinates (GRCh38): 8:66,712,781-66,862,022 (from NCBI)

This gene has 14 transcripts (splice variants), 212 orthologues and 13 paralogues. Ubiquitous expression in thyroid (RPKM 9.0), kidney (RPKM 5.7) and 25 other tissues.

Summary

This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

SGK3 Products (3)

mRNA	Protein	Name
NM_013257.5	NP_037389.4	serine/threonine-protein kinase Sgk3 isoform 1
NM_001033578.3	NP_001028750.1	serine/threonine-protein kinase Sgk3 isoform 1
NM_170709.3	NP_733827.2	serine/threonine-protein kinase Sgk3 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16888620	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SGK3 Protein Structure

Pkinase

Pkinase_C

0
100
200
300
400
496 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase Sgk3	cytokine-independent survival kinase

Recombinant SGK3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76063	SGK3 Protein, Human (Active, sf9, GST)	Q96BR1-1 (M1-L496)	≥ 80%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Noonan Syndrome 1	Noonan Syndrome NS1 Male Turner Syndrome Female Pseudo-Turner Syndrome Turner Phenotype With Normal Karyotype Noonan Syndrome With Pigmented Villonodular Synovitis Turner'S Phenotype, Karyotype Normal Familial Turner Syndrome Noonan'S Syndrome Noonan-Ehmke Syndrome Ns Pseudo-Ullrich-Turner Syndrome Turner Syndrome In Female With X Chromosome Turner-Like Syndrome Ullrich-Noonan Syndrome Noonan-Like/Multiple Giant Cell Lesion Syndrome Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions Pterygium Colli Syndrome Noonan Syndrome, Type 1 Turner Syndrome, Male
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125878	PROTAC SGK3 degrader-1	Inhibitor	99.89%	Unkown
HY-167832	PT109	Inhibitor	99.20%	Unkown
HY-170933	SGK1-IN-6	Inhibitor	/	Unkown
HY-176823	PROTAC SGK3 degrader-2	Degrader	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SGK3	VGNC	VGNC:81696
Mus musculus	SGK3	MGD	MGI:2182368
Rattus norvegicus	SGK3	RGD	RGD:620242