Pfkfb3 - 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Gene

Also Known as iPFK-2; uPFK-2; E330010H22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 170768

Summary

Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Predicted to be involved in fructose 2,6-bisphosphate metabolic process. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; integumental system; nervous system; sensory organ; and skeleton. Used to study extrinsic cardiomyopathy. Orthologous to human PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3). [provided by Alliance of Genome Resources, Apr 2022]

Pfkfb3 Products (8)

mRNA Protein Name
NM_001177752.1 NP_001171223.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 1
NM_001177753.1 NP_001171224.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 2
NM_001177754.1 NP_001171225.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 3
NM_001177755.1 NP_001171226.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 4
NM_001177756.1 NP_001171227.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 5
NM_001177757.1 NP_001171228.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 7
NM_001177758.1 NP_001171229.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 8
NM_133232.3 NP_573495.2 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 6

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within apoptotic process IMP
IMP: Inferred from mutant phenotype
35087090 MGI
acts upstream of or within glial cell differentiation IMP
IMP: Inferred from mutant phenotype
35087090 MGI
acts upstream of or within glycolytic process IMP
IMP: Inferred from mutant phenotype
35087090 MGI
acts upstream of or within motor behavior IMP
IMP: Inferred from mutant phenotype
35087090 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

  • inducible 6-phosphofructo-2-kinase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-12203 PFK-158 Inducer 98.95% Phase 1

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19824 3PO Inhibitor 99.85% Unkown
HY-12204 PFK-015 Inhibitor 99.48% Unkown
HY-101972 AZ-PFKFB3-67 Inhibitor 97.03% Unkown
HY-123981 5MPN 99.89% Unkown
HY-101971 AZ PFKFB3 26 Inhibitor 99.23% Unkown
HY-112808 KAN0438757 Inhibitor 99.41% Unkown
HY-110156 YZ9 Inhibitor 98.89% Unkown
HY-153077 PFKFB3-IN-2 Inhibitor 99.86% Unkown
HY-178367 PFKFB4-IN-1 99.91% Unkown
HY-RS10363 PFKFB3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-101972A AZ-PFKFB3-67 quarterhydrate Inhibitor 99.0% Unkown
HY-184148 PFKFB3-IN-3 Inhibitor / Unkown
HY-110169 (E/Z)-3PO Inhibitor 99.86% Unkown
HY-RS16558 Pfkfb3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22990 Pfkfb3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pfkfb3 NCBI NCBI:5209