Mef2a - myocyte enhancer factor 2A Gene

Also Known as A430079H05Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 17258

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including mitochondrion organization; positive regulation of macromolecule metabolic process; and ventricular cardiac myofibril assembly. Acts upstream of or within positive regulation of glucose import and positive regulation of transcription, DNA-templated. Located in chromatin and nucleus. Is expressed in several structures, including brain; cardiovascular system; embryo mesenchyme; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human MEF2A (myocyte enhancer factor 2A). [provided by Alliance of Genome Resources, Apr 2022]

Mef2a Products (7)

mRNA	Protein	Name
NM_001033713.2	NP_001028885.1	myocyte-specific enhancer factor 2A isoform a
NM_001291191.2	NP_001278120.1	myocyte-specific enhancer factor 2A isoform b
NM_001291192.1	NP_001278121.1	myocyte-specific enhancer factor 2A isoform b
NM_001291195.1	NP_001278124.1	myocyte-specific enhancer factor 2A isoform c
NM_001291196.1	NP_001278125.1	myocyte-specific enhancer factor 2A isoform d
NM_001357324.1	NP_001344253.1	myocyte-specific enhancer factor 2A isoform e
NM_001357325.1	NP_001344254.1	myocyte-specific enhancer factor 2A isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	9738004	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	16407236	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	9738004	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	21379568	MGI
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	11160896	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9430690	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	16407236	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7973707	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	17785444	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8096811	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cardiac conduction	IMP IMP: Inferred from mutant phenotype	12379849	MGI
involved in mitochondrial genome maintenance	IMP IMP: Inferred from mutant phenotype	12379849	MGI
involved in mitochondrion distribution	IMP IMP: Inferred from mutant phenotype	12379849	MGI
acts upstream of or within positive regulation of D-glucose import	IDA IDA: Inferred from direct assay	12097321	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12097321	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	29606596	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16407236	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	8900141	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9738004	MGI
involved in ventricular cardiac myofibril assembly	IMP IMP: Inferred from mutant phenotype	12379849	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	20833138	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9013788	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
myocyte-specific enhancer factor 2A

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08309	MEF2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174584	Human MEF2A mRNA		/	Unkown
HY-RS19713	Mef2a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26209	Mef2a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mef2a	NCBI	NCBI:4205