MEF2A - myocyte enhancer factor 2A Gene

Also Known as mef2; ADCAD1; RSRFC4; RSRFC9

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4205

About MEF2A

Cytogenetic location: 15q26.3 Genomic coordinates (GRCh38): 15:99,565,417-99,716,488 (from NCBI)

This gene has 18 transcripts (splice variants), 203 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in heart (RPKM 14.6), brain (RPKM 12.2) and 25 other tissues.

Summary

The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and Apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]

MEF2A Products (62)

mRNA Protein Name
NM_001130926.5 NP_001124398.1 myocyte-specific enhancer factor 2A isoform 2
NM_001130927.5 NP_001124399.1 myocyte-specific enhancer factor 2A isoform 3
NM_001130928.4 NP_001124400.1 myocyte-specific enhancer factor 2A isoform 4
NM_001171894.5 NP_001165365.1 myocyte-specific enhancer factor 2A isoform 2
NM_001319206.4 NP_001306135.1 myocyte-specific enhancer factor 2A isoform 5
NM_001352614.4 NP_001339543.1 myocyte-specific enhancer factor 2A isoform 2
NM_001352615.4 NP_001339544.1 myocyte-specific enhancer factor 2A isoform 2
NM_001352616.4 NP_001339545.1 myocyte-specific enhancer factor 2A isoform 5
NM_001352617.4 NP_001339546.1 myocyte-specific enhancer factor 2A isoform 1
NM_001352618.4 NP_001339547.1 myocyte-specific enhancer factor 2A isoform 6
NM_001365201.3 NP_001352130.1 myocyte-specific enhancer factor 2A isoform 7
NM_001365202.3 NP_001352131.1 myocyte-specific enhancer factor 2A isoform 7
NM_001365203.3 NP_001352132.1 myocyte-specific enhancer factor 2A isoform 8
NM_001365204.3 NP_001352133.1 myocyte-specific enhancer factor 2A isoform 8
NM_001365205.3 NP_001352134.1 myocyte-specific enhancer factor 2A isoform 5
NM_001365206.3 NP_001352135.1 myocyte-specific enhancer factor 2A isoform 6
NM_001365207.3 NP_001352136.1 myocyte-specific enhancer factor 2A isoform 1
NM_001365208.3 NP_001352137.1 myocyte-specific enhancer factor 2A isoform 2
NM_001365209.3 NP_001352138.1 myocyte-specific enhancer factor 2A isoform 3
NM_001365210.2 NP_001352139.1 myocyte-specific enhancer factor 2A isoform 10
NM_001365211.2 NP_001352140.1 myocyte-specific enhancer factor 2A isoform 11
NM_001393558.2 NP_001380487.1 myocyte-specific enhancer factor 2A isoform 12
NM_001393559.2 NP_001380488.1 myocyte-specific enhancer factor 2A isoform 4
NM_001393560.2 NP_001380489.1 myocyte-specific enhancer factor 2A isoform 13
NM_001393561.3 NP_001380490.1 myocyte-specific enhancer factor 2A isoform 14
NM_001400028.1 NP_001386957.1 myocyte-specific enhancer factor 2A isoform 15
NM_001400029.1 NP_001386958.1 myocyte-specific enhancer factor 2A isoform 8
NM_001400030.1 NP_001386959.1 myocyte-specific enhancer factor 2A isoform 8
NM_001400031.1 NP_001386960.1 myocyte-specific enhancer factor 2A isoform 5
NM_001400032.1 NP_001386961.1 myocyte-specific enhancer factor 2A isoform 5
NM_001400033.1 NP_001386962.1 myocyte-specific enhancer factor 2A isoform 5
NM_001400034.1 NP_001386963.1 myocyte-specific enhancer factor 2A isoform 5
NM_001400035.1 NP_001386964.1 myocyte-specific enhancer factor 2A isoform 5
NM_001400036.1 NP_001386965.1 myocyte-specific enhancer factor 2A isoform 5
NM_001400037.1 NP_001386966.1 myocyte-specific enhancer factor 2A isoform 6
NM_001400038.1 NP_001386967.1 myocyte-specific enhancer factor 2A isoform 1
NM_001400039.1 NP_001386968.1 myocyte-specific enhancer factor 2A isoform 1
NM_001400040.1 NP_001386969.1 myocyte-specific enhancer factor 2A isoform 1
NM_001400049.1 NP_001386978.1 myocyte-specific enhancer factor 2A isoform 1
NM_001400050.1 NP_001386979.1 myocyte-specific enhancer factor 2A isoform 1
NM_001400051.1 NP_001386980.1 myocyte-specific enhancer factor 2A isoform 1
NM_001400052.1 NP_001386981.1 myocyte-specific enhancer factor 2A isoform 1
NM_001400053.1 NP_001386982.1 myocyte-specific enhancer factor 2A isoform 1
NM_001400054.1 NP_001386983.1 myocyte-specific enhancer factor 2A isoform 2
NM_001400055.1 NP_001386984.1 myocyte-specific enhancer factor 2A isoform 2
NM_001400056.1 NP_001386985.1 myocyte-specific enhancer factor 2A isoform 2
NM_001400057.1 NP_001386986.1 myocyte-specific enhancer factor 2A isoform 2
NM_001400058.1 NP_001386987.1 myocyte-specific enhancer factor 2A isoform 2
NM_001400059.1 NP_001386988.1 myocyte-specific enhancer factor 2A isoform 2
NM_001400060.1 NP_001386989.1 myocyte-specific enhancer factor 2A isoform 2
NM_001400061.1 NP_001386990.1 myocyte-specific enhancer factor 2A isoform 2
NM_001400062.1 NP_001386991.1 myocyte-specific enhancer factor 2A isoform 2
NM_001400063.1 NP_001386992.1 myocyte-specific enhancer factor 2A isoform 2
NM_001400064.1 NP_001386993.1 myocyte-specific enhancer factor 2A isoform 2
NM_001400065.1 NP_001386994.1 myocyte-specific enhancer factor 2A isoform 2
NM_001400066.1 NP_001386995.1 myocyte-specific enhancer factor 2A isoform 2
NM_001400067.1 NP_001386996.1 myocyte-specific enhancer factor 2A isoform 16
NM_001400068.1 NP_001386997.1 myocyte-specific enhancer factor 2A isoform 12
NM_001400069.1 NP_001386998.1 myocyte-specific enhancer factor 2A isoform 17
NM_001400070.1 NP_001386999.1 myocyte-specific enhancer factor 2A isoform 11
NM_001400071.1 NP_001387000.1 myocyte-specific enhancer factor 2A isoform 11
NM_005587.6 NP_005578.2 myocyte-specific enhancer factor 2A isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
7760790 GOA
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
16043483 GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
10748098 GOA
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
20590529 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
7760790 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
20590529 GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
15466416 GOA
enables SMAD binding IPI
IPI: Inferred from physical interaction
11160896 GOA
enables chromatin binding IDA
IDA: Inferred from direct assay
21468593 GOA
enables histone acetyltransferase binding IPI
IPI: Inferred from physical interaction
20590529 GOA
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
10748098 GOA
contributes to protein binding IPI
IPI: Inferred from physical interaction
16043483 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7973707 GOA
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
9858528 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10835359 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA-templated transcription IDA
IDA: Inferred from direct assay
16043483 GOA
involved in ERK5 cascade IMP
IMP: Inferred from mutant phenotype
15132737 GOA
involved in MAPK cascade IDA
IDA: Inferred from direct assay
9858528 GOA
involved in cellular response to calcium ion IDA
IDA: Inferred from direct assay
16484498 GOA
involved in heart development IEP
IEP: Inferred from expression pattern
10458488 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16484498 GOA
involved in positive regulation of cardiac muscle hypertrophy IDA
IDA: Inferred from direct assay
24161931 GOA
involved in positive regulation of cardiac muscle hypertrophy IGI
IGI: Inferred from genetic interaction
24161931 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
7760790 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
16484498 GOA
part of transcription regulator complex IDA
IDA: Inferred from direct assay
16043483 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MEF2A Protein Structure

SRF-TF

SRF-TF: SRF-type transcription factor (DNA-binding and dimerisation domain) (10 - 59)

HJURP_C

HJURP_C: Holliday junction regulator protein family C-terminal repeat (90 - 154)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 499 a.a.
Protein Preferred Names Protein Names

myocyte-specific enhancer factor 2A

  • MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)

MEF2A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MEF2A Q02078 PITX2 Homo sapiens Q99697-3
Pull Down
15466416
Cross
MEF2A Q02078 Nfix Mus musculus P70257-2
Anti Tag CoIP
20178747
Cross
MEF2A Q02078 Myod1 Mus musculus P10085
Pull Down
7973707
Cross: Cross-species interaction Intra: Intraspecies interaction

MEF2A Antibodies

Cat. No. 상품명 신청 Reactivity
HY-P83464 MEF2A Antibody (YA3209) WB, ICC/IF Human, Mouse, Rat
HY-P83464A MEF2A Antibody (YA3209)(PBS only) WB, ICC/IF Human, Mouse, Rat
HY-P83579 MEF2A Antibody (YA3324) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Coronary Artery Disease, Autosomal Dominant, 1

  • ADCAD1

  • Coronary Artery Disease With Myocardial Infarction

  • Coronary Artery Disease/Myocardial Infarction

  • Artery, Coronary, Disease, Autosomal Dominant, Type 1
Myocardial Infarction

  • Heart Attack

  • Myocardial Infarction, Susceptibility To

  • Myocardial Infarction 1

  • Myocardial Infarction, Protection Against

  • Myocardial Infarction, Decreased Susceptibility To

  • Myocardial Infarction, Decreased

  • Myocardial Infarct

  • MCI1

  • Premature Myocardial Infarction

  • Myocardial Infarction, Susceptibility To, Type 1
Muscle Hypertrophy

  • MSLHP

  • Hypertrophy

  • Hypertrophy, Muscle
Heart Disease

  • Heart Failure

  • Congenital Heart Disease

  • Heart Diseases

  • Congenital Heart Defects

  • Congenital Heart Defect

  • Heart Malformation

  • Congenital Anomaly Of Heart

  • Heart Defect

  • Heart-Congenital Defect

  • Congenital Heart Disorder

  • Heart Defects Congenital

  • Heart Defects, Congenital

  • Heart Defects

  • Heart Disease, Congenital

  • Disease, Heart, Congenital

  • Congestive Heart Failure
Ichthyosis, Congenital, Autosomal Recessive 9

  • Autosomal Recessive Congenital Ichthyosis 9

  • ARCI9

  • Ichthyosis, Congenital, Autosomal Recessive, Type 9
Brachydactyly, Type E1

  • Brachydactyly Type E1

  • Brachydactyly Type E

  • BDE1

  • Brachydactyly, Type E

  • Bde

  • Type E Brachydactyly

  • Brachydactyly E1

  • Brachydactyly Syndrome Type E
Lipoprotein Quantitative Trait Locus

  • Coronary Artery Disease

  • Coronary Artery Anomaly

  • Coronary Artery Disease, Susceptibility To

  • Myocardial Ischemia

  • Congenital Anomaly Of Coronary Artery

  • Coronary Arteriosclerosis

  • Coronary Disease

  • Coronary Heart Disease

  • Coronary Artery Disorder

  • LPAQTL

  • Lpa Deficiency, Congenital

  • Coronary Artery Abnormality

  • Coronary Artery Anomaly, Congenital

  • Chd

  • Coronary Syndrome

  • Congenital Malformations Of Coronary Vessels

  • Malformation Of Coronary Vessels

  • Congenital Coronary Artery Anomaly

  • Congenital Coronary Artery Deformity

  • Congenital Coronary Artery Disorder

  • Abnormal Coronary Artery

  • Congenital Coronary Artery Malposition

  • Congenital Coronary Disease

  • Congenital Anomaly Of Coronary Arteries
Rhabdomyosarcoma
Microphthalmia

  • Microphthalmos

  • Isolated Anophthalmia-Microphthalmia Syndrome

  • Isolated Microphthalmia-Anophthalmia-Coloboma

  • Simple Microphthalmos

  • Clinical Anophthalmia

  • Isolated Anophthalmia - Microphthalmia

  • Isolated Pure Microphthalmia

  • Mac Spectrum

  • Microphthalmia-Anophthalmia-Coloboma Spectrum

  • Primitive Anophthalmia

  • Globe Of Eye Small

  • Small Eyeball

  • Hypoplasia Of Eye

  • Isolated Nanophthalmos

  • Rudimentary Eye

  • Dysplasia Of Eye
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Hypertrophic Cardiomyopathy

  • Hypertrophic Obstructive Cardiomyopathy

  • Cardiomyopathy, Hypertrophic

  • Cardiomyopathy Hypertrophic Obstructive

  • Cardiomyopathy, Hypertrophic, Familial

  • Idiopathic Myocardial Hypertrophy

  • Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Idiopathic Hypertrophic Cardiomyopathy

  • Obstructive Cardiomyopathy

  • Idiopathic Hypertrophic Subaortic Stenosis

  • Muscular Subaortic Stenosis

  • Hypertrophic Obstructive Subaortic Stenosis
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS08309 MEF2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174584 Human MEF2A mRNA / Unkown
HY-RS19713 Mef2a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26209 Mef2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MEF2A VGNC VGNC:31372
Mus musculus MEF2A MGD MGI:99532
Felis catus MEF2A VGNC VGNC:68229
Macaca mulatta MEF2A VGNC VGNC:74698
Rattus norvegicus MEF2A RGD RGD:1359360
Canis familiaris MEF2A VGNC VGNC:43143
Others MEF2A NCBI