Mgat3 - mannoside acetylglucosaminyltransferase 3 Gene

Also Known as GnT-III; 1110038J12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17309

Summary

Enables beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity. Acts upstream of or within several processes, including amyloid-beta metabolic process; negative regulation of lysosomal protein catabolic process; and positive regulation of protein localization to early endosome. Is expressed in several structures, including alimentary system; metanephros; and nervous system. Orthologous to human MGAT3 (beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Mgat3 Products (1)

mRNA Protein Name
NM_010795.4 NP_034925.2 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity IMP
IMP: Inferred from mutant phenotype
25592972 MGI
enables glycosyltransferase activity IDA
IDA: Inferred from direct assay
24619415 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within N-acetylglucosamine metabolic process IDA
IDA: Inferred from direct assay
24619415 MGI
acts upstream of or within amyloid-beta metabolic process IMP
IMP: Inferred from mutant phenotype
25592972 MGI
acts upstream of or within cellular response to oxidative stress IMP
IMP: Inferred from mutant phenotype
26467158 MGI
acts upstream of or within cognition IMP
IMP: Inferred from mutant phenotype
25592972 MGI
acts upstream of lysosomal protein catabolic process IMP
IMP: Inferred from mutant phenotype
25592972 MGI
acts upstream of or within negative regulation of lysosomal protein catabolic process IMP
IMP: Inferred from mutant phenotype
25592972 MGI
acts upstream of or within positive regulation of protein localization to early endosome IMP
IMP: Inferred from mutant phenotype
25592972 MGI
acts upstream of or within protein N-linked glycosylation IMP
IMP: Inferred from mutant phenotype
25592972 MGI
acts upstream of protein localization to early endosome IMP
IMP: Inferred from mutant phenotype
25592972 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

  • N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III

  • glcNAc-T III

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-138942 PF-06427878 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-32219 T863 Inhibitor 99.83% Unkown
HY-103504 (S)-SNAP5114 Inhibitor 98.09% Unkown
HY-108339 PF-06471553 Inhibitor 98.29% Unkown
HY-146280 mGAT3/4-IN-1 Inhibitor / Unkown
HY-146281 mGAT3/4-IN-2 Inhibitor / Unkown
HY-146282 mGAT-IN-1 Inhibitor / Unkown
HY-RS08403 MGAT3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20988 Mgat3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27505 Mgat3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mgat3 NCBI NCBI:4248