Mid1 - midline 1 Gene

Also Known as Fxy; 61B3-R; Trim18; DXHXS1141

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17318

Summary

Predicted to enable several functions, including microtubule binding activity; protein homodimerization activity; and ubiquitin protein Ligase binding activity. Acts upstream of or within negative regulation of microtubule depolymerization. Located in cytoplasm and microtubule Cytoskeleton. Is expressed in several structures, including 1st branchial arch; alimentary system; brain; genitourinary system; and sensory organ. Used to study Opitz-GBBB syndrome and microphthalmia. Human ortholog(s) of this gene implicated in Opitz GBBB syndrome type I. Orthologous to human MID1 (midline 1). [provided by Alliance of Genome Resources, Apr 2022]

Mid1 Products (5)

mRNA Protein Name
NM_001290504.1 NP_001277433.1 E3 ubiquitin-protein ligase Midline-1 isoform 2
NM_001290505.1 NP_001277434.1 E3 ubiquitin-protein ligase Midline-1 isoform 2
NM_001290506.1 NP_001277435.1 E3 ubiquitin-protein ligase Midline-1 isoform 3
NM_001290512.1 NP_001277441.1 E3 ubiquitin-protein ligase Midline-1 isoform 4
NM_010797.3 NP_034927.2 E3 ubiquitin-protein ligase Midline-1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15070402 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of microtubule depolymerization IGI
IGI: Inferred from genetic interaction
15070402 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15070402 MGI
located in microtubule cytoskeleton IDA
IDA: Inferred from direct assay
15070402 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase Midline-1

  • RING finger protein Midline-1

  • RING-type E3 ubiquitin transferase Midline-1

  • midin

  • tripartite motif-containing protein 18

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-115461 MID-1 Inhibitor 99.67% Phase 2

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08434 MID1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08435 MID1IP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08611 MPG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18738 Mpg Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18951 Mid1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19281 Mid1ip1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25441 Mid1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25771 Mid1ip1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mid1 NCBI NCBI:4281