Mt3 - metallothionein 3 Gene

Also Known as Mt-3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17751

Summary

Enables zinc ion binding activity. Involved in several processes, including negative regulation of cell death; regulation of cellular macromolecule biosynthetic process; and transition metal ion homeostasis. Acts upstream of or within cellular metal ion homeostasis and negative regulation of neurogenesis. Located in synaptic vesicle. Is expressed in brain; decidua; ganglia; ventral grey horn; and ventricular layer. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human MT3 (metallothionein 3). [provided by Alliance of Genome Resources, Apr 2022]

Mt3 Products (1)

mRNA Protein Name
NM_013603.2 NP_038631.1 metallothionein-3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables metal ion binding IDA
IDA: Inferred from direct assay
12130647 MGI
enables zinc ion binding IDA
IDA: Inferred from direct assay
7931547 MGI
Biological Process GO Annotation Evidence References Source
involved in detoxification of cadmium ion IMP
IMP: Inferred from mutant phenotype
20371971 MGI
involved in energy reserve metabolic process IMP
IMP: Inferred from mutant phenotype
21726645 MGI
acts upstream of or within intracellular monoatomic cation homeostasis IDA
IDA: Inferred from direct assay
12130647 MGI
involved in intracellular zinc ion homeostasis IDA
IDA: Inferred from direct assay
20544854 MGI
involved in intracellular zinc ion homeostasis IMP
IMP: Inferred from mutant phenotype
21726645 MGI
involved in leptin-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
21726645 MGI
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
19635467 MGI
acts upstream of or within negative regulation of neurogenesis IDA
IDA: Inferred from direct assay
12130647 MGI
involved in negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
21359432 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
21726645 MGI
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
21726645 MGI
involved in positive regulation of oxygen metabolic process IMP
IMP: Inferred from mutant phenotype
21726645 MGI
involved in regulation of response to food IMP
IMP: Inferred from mutant phenotype
21726645 MGI
involved in response to oxidative stress IMP
IMP: Inferred from mutant phenotype
19635467 MGI
involved in sequestering of metal ion IMP
IMP: Inferred from mutant phenotype
20371971 MGI
involved in zinc ion transport IDA
IDA: Inferred from direct assay
21359432 MGI
Cellular Component GO Annotation Evidence References Source
located in synaptic vesicle IDA
IDA: Inferred from direct assay
7931547 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

metallothionein-3

  • GIF

  • MT-III

  • growth inhibitory factor

  • metallothionein-III

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-128206 I3MT-3 Inhibitor 99.76% Unkown
HY-P5846 Muscarinic toxin 3 Antagonist / Unkown
HY-RS08744 MT3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19565 Mt3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26061 Mt3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mt3 NCBI NCBI:4504