Mtf1 - metal response element binding transcription factor 1 Gene

Also Known as MTF-1; Thyls

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17764

Summary

Enables DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and Histone Acetyltransferase binding activity. Involved in cellular response to zinc ion and transcription, DNA-templated. Acts upstream of or within positive regulation of transcription by RNA polymerase II; response to cadmium ion; and response to oxidative stress. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; cardiovascular system; early conceptus; genitourinary system; and gut. Orthologous to human MTF1 (metal regulatory transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Mtf1 Products (1)

mRNA Protein Name
NM_008636.4 NP_032662.3 metal regulatory transcription factor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
10952993 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
18605988 MGI
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
9582278 MGI
enables histone acetyltransferase binding IPI
IPI: Inferred from physical interaction
18605988 MGI
Biological Process GO Annotation Evidence References Source
involved in DNA-templated transcription IDA
IDA: Inferred from direct assay
24529376 MGI
acts upstream of cartilage homeostasis IMP
IMP: Inferred from mutant phenotype
24529376 MGI
involved in cellular response to zinc ion IDA
IDA: Inferred from direct assay
24529376 MGI
acts upstream of or within positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
10952993 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9582278 MGI
acts upstream of or within response to cadmium ion IMP
IMP: Inferred from mutant phenotype
9582278 MGI
acts upstream of or within response to oxidative stress IMP
IMP: Inferred from mutant phenotype
9582278 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
24529376 MGI
located in nucleus IDA
IDA: Inferred from direct assay
24529376 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

metal regulatory transcription factor 1

  • MRE-binding transcription factor

  • metalloregulatory transcription factor

  • transcription factor MTF-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS19922 Mtf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08331 MELTF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08765 MTF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08973 MYT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26424 Mtf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mtf1 NCBI NCBI:4520