MTF1 - metal regulatory transcription factor 1 Gene

Also Known as ZRF; MTF-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4520

About MTF1

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:37,809,574-37,859,592 (from NCBI)

This gene has 2 transcripts (splice variants), 209 orthologues, 36 paralogues and is associated with 1 phenotype. Ubiquitous expression in bone marrow (RPKM 7.9), testis (RPKM 4.9) and 25 other tissues.

Summary

This gene encodes a transcription factor that induces expression of metallothioneins and Other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE). [provided by RefSeq, Jul 2008]

MTF1 Products (1)

mRNA Protein Name
NM_005955.3 NP_005946.2 metal regulatory transcription factor 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
9582278 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
9582278 GOA
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15735762 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9582278 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MTF1 Protein Structure

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (140 - 164)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (186 - 213)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (245 - 271)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (275 - 302)

  • 0
  • 200
  • 400
  • 600
  • 753 a.a.
Protein Preferred Names Protein Names

metal regulatory transcription factor 1

  • MRE-binding transcription factor

MTF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MTF1 Q14872 AP1M1 Homo sapiens Q9BXS5
Y2H Pooling
16189514
Cross: Cross-species interaction Intra: Intraspecies interaction

MTF1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P86967 MTF1 Antibody (YA6660) WB, ICC/IF, IHC-P, FC Human

Related Diseases

Diseases Alias
Dentine Erosion
Enamel Erosion
Tooth Erosion

  • Generalized Erosion

  • Localized Erosion

  • Generalized Erosions

  • Erosion, Localized
Atrial Septal Defect 2

  • ASD2

  • Atrial Heart Septal Defect 2

  • Atrial Septal Defect-2

  • Asd Ii

  • Septal Defect, Atrial, Type 2
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS19922 Mtf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08331 MELTF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08765 MTF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08973 MYT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26424 Mtf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MTF1 VGNC VGNC:43466
Mus musculus MTF1 MGD MGI:101786
Bos taurus MTF1 VGNC VGNC:31722
Rattus norvegicus MTF1 RGD RGD:1308956
Macaca mulatta MTF1 VGNC VGNC:74946
Felis catus MTF1 VGNC VGNC:68338
Others MTF1 NCBI