Nck1 - non-catalytic region of tyrosine kinase adaptor protein 1 Gene

Also Known as Nck; Nck-1; 6330586M15Rik; D230010O13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17973

Summary

Enables Ephrin Receptor binding activity; eukaryotic initiation factor eIF2 binding activity; and protein domain specific binding activity. Involved in regulation of cellular macromolecule biosynthetic process and regulation of response to endoplasmic reticulum stress. Acts upstream of or within several processes, including Ephrin Receptor signaling pathway; plasma membrane bounded cell projection assembly; and positive regulation of cellular component organization. Located in cell-cell junction and vesicle membrane. Is expressed in several structures, including extraembryonic component; hemolymphoid system gland; male reproductive gland or organ; nervous system; and somite. Orthologous to human NCK1 (NCK adaptor protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Nck1 Products (2)

mRNA Protein Name
NM_001324530.1 NP_001311459.1 cytoplasmic protein NCK1 isoform 2
NM_010878.3 NP_035008.2 cytoplasmic protein NCK1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ephrin receptor binding IPI
IPI: Inferred from physical interaction
19505147 MGI
enables eukaryotic initiation factor eIF2 binding IPI
IPI: Inferred from physical interaction
11959995 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14580336 MGI
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
8438166 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin filament organization IMP
IMP: Inferred from mutant phenotype
12637565 MGI
acts upstream of or within cell migration IMP
IMP: Inferred from mutant phenotype
12637565 MGI
acts upstream of or within ephrin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
19505147 MGI
acts upstream of or within lamellipodium assembly IMP
IMP: Inferred from mutant phenotype
12808099 MGI
involved in negative regulation of PERK-mediated unfolded protein response IGI
IGI: Inferred from genetic interaction
14676213 MGI
involved in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IGI
IGI: Inferred from genetic interaction
14676213 MGI
involved in negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16835242 MGI
acts upstream of or within positive regulation of actin filament polymerization IGI
IGI: Inferred from genetic interaction
17923684 MGI
involved in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
16835242 MGI
acts upstream of or within positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
19505147 MGI
involved in positive regulation of translation in response to endoplasmic reticulum stress IGI
IGI: Inferred from genetic interaction
14676213 MGI
acts upstream of or within regulation of cell migration IGI
IGI: Inferred from genetic interaction
19505147 MGI
involved in response to endoplasmic reticulum stress IGI
IGI: Inferred from genetic interaction
16835242 MGI
acts upstream of or within response to other organism IMP
IMP: Inferred from mutant phenotype
22966049 MGI
acts upstream of or within substrate-dependent cell migration, cell extension IGI
IGI: Inferred from genetic interaction
19414610 MGI
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
23793062 MGI
located in vesicle membrane IDA
IDA: Inferred from direct assay
12147689 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytoplasmic protein NCK1

  • NCK adaptor protein 1

Nck1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Nck1 Q99M51 Tnk2 Mus musculus O54967
Anti Bait CoIP
16777958
Intra
Nck1 Q99M51 Abl1 Mus musculus P00520
Anti Tag CoIP
15148308
Intra
Nck1 Q99M51 Dok1 Mus musculus P97465
Anti Tag CoIP
15148308
Intra
Nck1 Q99M51 Dok1 Mus musculus P97465
Pull Down
20697350
Intra
Nck1 Q99M51 Dok1 Mus musculus P97465
Anti Bait CoIP
15148308
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09080 NCK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18777 Nck1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25265 Nck1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nck1 NCBI NCBI:4690