Tnk2 - tyrosine kinase, non-receptor, 2 Gene

Also Known as Ack; Ack1; Pyk1; Ack-1; Cdgip

Species: Mus musculus

Gene Type: protein coding
Gene ID: 51789

Summary

Enables WW domain binding activity. Involved in spermatid development. Located in several cellular components, including endosome; growth cone; and neuronal cell body. Is expressed in several structures, including alimentary system; liver; nervous system; retina; and vibrissa. Orthologous to human TNK2 (tyrosine kinase non receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Tnk2 Products (4)

mRNA Protein Name
NM_001110147.1 NP_001103617.1 activated CDC42 kinase 1 isoform 2
NM_001289443.1 NP_001276372.1 activated CDC42 kinase 1 isoform 3
NM_001347185.1 NP_001334114.1 activated CDC42 kinase 1 isoform 4
NM_016788.3 NP_058068.2 activated CDC42 kinase 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables WW domain binding IPI
IPI: Inferred from physical interaction
20086093 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16052498 MGI
Biological Process GO Annotation Evidence References Source
involved in spermatid development IGI
IGI: Inferred from genetic interaction
23562806 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
16052498 MGI
located in dendrite IDA
IDA: Inferred from direct assay
16052498 MGI
located in endosome IDA
IDA: Inferred from direct assay
17182860 MGI
located in growth cone IDA
IDA: Inferred from direct assay
16052498 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
16052498 MGI
located in nucleus IDA
IDA: Inferred from direct assay
20333297 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
20333297 MGI
is active in postsynaptic cytosol IDA
IDA: Inferred from direct assay
16052498 MGI
is active in presynaptic cytosol IDA
IDA: Inferred from direct assay
16052498 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

activated CDC42 kinase 1

  • Cdc42 GTPase-inhibiting protein

  • P21cdc42Hs kinase

  • non-receptor protein tyrosine kinase ACK

  • tyrosine kinase non-receptor protein 2

Tnk2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Tnk2 O54967 NCK1 Homo sapiens P16333-1
Anti Bait CoIP
16777958
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-12418 Stenoparib Inhibitor 98.0% Phase 2
HY-147245 Basroparib Inhibitor 98.91% Phase 1

Pre-clinical Phase

Bioactive Molecules (44)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15147 XAV-939 Inhibitor 99.91% Unkown
HY-16910 WIKI4 Inhibitor 99.93% Unkown
HY-13990 NVP-TNKS656 99.68% Unkown
HY-12438 G007-LK Inhibitor 99.24% Unkown
HY-123851 MSC2504877 Inhibitor 99.25% Unkown
HY-12975 AZ6102 Inhibitor 99.53% Unkown
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-15811 XMD8-87 Inhibitor 99.57% Unkown
HY-19351 MN-64 Inhibitor 99.61% Unkown
HY-101243 XMD16-5 Inhibitor 98.20% Unkown
HY-148061 DB1113 99.86% Unkown
HY-U00422 K-756 Inhibitor 99.25% Unkown
HY-148063 DB0614 99.92% Unkown
HY-126248 Tankyrase-IN-2 99.06% Unkown
HY-147886 PARP1-IN-11 Inhibitor 99.42% Unkown
HY-121719 TIQ-A Inhibitor 99.85% Unkown
HY-156332 TNKS-2-IN-2 Inhibitor 99.47% Unkown
HY-164478 G-631 Inhibitor 99.88% Unkown
HY-12577 TNKS1/2-IN-1 Inhibitor 99.24% Unkown
HY-143338 ART-IN-1 Inhibitor 98.91% Unkown
HY-146336 PARP1/2/TNKS1/2-IN-1 98.66% Unkown
HY-173349 TDI-012804 Inhibitor / Unkown
HY-23338 TNKS-2-IN-1 Inhibitor 95.03% Unkown
HY-100847 AZ0108 Inhibitor / Unkown
HY-114943 TNKS-IN-1 Inhibitor 99.55% Unkown
HY-12601 TNKS 22 Inhibitor / Unkown
HY-12602 TNKS-IN-4 Inhibitor / Unkown
HY-13990G NVP-TNKS656 (GMP) / Unkown
HY-145111 TNK2-IN-1 Inhibitor / Unkown
HY-153259 TNKS1/2-IN-2 Inhibitor / Unkown
HY-156745 PROTAC DDa-1 Degrader / Unkown
HY-167762 TNKS-2-IN-4 Inhibitor / Unkown
HY-172747 TNKS-2-IN-3 Inhibitor / Unkown
HY-180926 PARP10-IN-4 Inhibitor / Unkown
HY-E70868 TNK1 Recombinant Human Active Protein Kinase / Unkown
HY-RS14838 TNK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14843 TNKS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14844 Tnks2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14845 TNKS2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-153332 Tankyrase-IN-5 Inhibitor / Unkown
HY-168925 EXQ-2d Inhibitor / Unkown
HY-173480 TNKS-IN-3 Inhibitor / Unkown
HY-RS16928 Tnk2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23371 Tnk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnk2 NCBI NCBI:10188