TNK2 - tyrosine kinase non receptor 2 Gene

Also Known as ACK; ACK1; ACK-1; p21cdc42Hs

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10188

About TNK2

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:195,863,364-195,908,551 (from NCBI)

This gene has 31 transcripts (splice variants), 153 orthologues, 32 paralogues and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 21.9), bone marrow (RPKM 14.7) and 24 other tissues.

Summary

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 Amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]

TNK2 Products (24)

mRNA	Protein	Name
NM_001010938.2	NP_001010938.2	activated CDC42 kinase 1 isoform 2
NM_001308046.2	NP_001294975.1	activated CDC42 kinase 1 isoform 3
NM_001382271.1	NP_001369200.1	activated CDC42 kinase 1 isoform 4
NM_001382272.1	NP_001369201.1	activated CDC42 kinase 1 isoform 5
NM_001382273.1	NP_001369202.1	activated CDC42 kinase 1 isoform 6
NM_001382274.1	NP_001369203.1	activated CDC42 kinase 1 isoform 6
NM_001382275.1	NP_001369204.1	activated CDC42 kinase 1 isoform 7
NM_001386164.1	NP_001373093.1	activated CDC42 kinase 1 isoform 8
NM_001387707.1	NP_001374636.1	activated CDC42 kinase 1 isoform 9
NM_001387708.1	NP_001374637.1	activated CDC42 kinase 1 isoform 10
NM_001387709.1	NP_001374638.1	activated CDC42 kinase 1 isoform 8
NM_001387710.1	NP_001374639.1	activated CDC42 kinase 1 isoform 8
NM_001387711.1	NP_001374640.1	activated CDC42 kinase 1 isoform 8
NM_001387712.1	NP_001374641.1	activated CDC42 kinase 1 isoform 8
NM_001387713.1	NP_001374642.1	activated CDC42 kinase 1 isoform 1
NM_001387714.1	NP_001374643.1	activated CDC42 kinase 1 isoform 1
NM_001387715.1	NP_001374644.1	activated CDC42 kinase 1 isoform 11
NM_001387716.1	NP_001374645.1	activated CDC42 kinase 1 isoform 12
NM_001387717.1	NP_001374646.1	activated CDC42 kinase 1 isoform 12
NM_001387718.1	NP_001374647.1	activated CDC42 kinase 1 isoform 12
NM_001387719.1	NP_001374648.1	activated CDC42 kinase 1 isoform 13
NM_001387720.1	NP_001374649.1	activated CDC42 kinase 1 isoform 13
NM_001387721.1	NP_001374650.1	activated CDC42 kinase 1 isoform 13
NM_005781.5	NP_005772.3	activated CDC42 kinase 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables epidermal growth factor receptor binding	IDA IDA: Inferred from direct assay	20086093	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16472662	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10360579	GOA
enables protein serine/threonine/tyrosine kinase activity	IDA IDA: Inferred from direct assay	16257963	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	18993068	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	23686771	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in phosphorylation	IDA IDA: Inferred from direct assay	20333297	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	10587647	GOA
involved in regulation of clathrin-dependent endocytosis	IDA IDA: Inferred from direct assay	18262180	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Grb2-EGFR complex	IDA IDA: Inferred from direct assay	20086093	GOA
located in clathrin-coated pit	IDA IDA: Inferred from direct assay	21169560	GOA
located in clathrin-coated vesicle	IDA IDA: Inferred from direct assay	18262180	GOA
located in cytoophidium	IDA IDA: Inferred from direct assay	25223282	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	20979614	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20333297	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	20333297	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNK2 Protein Structure

Pkinase_Tyr

SH3_9

GTPase_binding

Inhibitor_Mig-6

0
200
400
600
800
1038 a.a.

Protein Preferred Names	Protein Names
activated CDC42 kinase 1	activated Cdc42-associated kinase 1

TNK2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TNK2	Q07912	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	31980649
Intra	TNK2	Q07912	CLTC	Homo sapiens	Q00610	Anti Tag CoIP	16137687
Intra	TNK2	Q07912	NCK1	Homo sapiens	P16333	Peptide Array	16137687
Intra	TNK2	Q07912	386682	Homo sapiens	EBI-10171679	Y2H Array	25416956
Intra	TNK2	Q07912	AQP1	Homo sapiens	P29972	Y2H Prey Pooling	25416956
Intra	TNK2	Q07912	GRB2	Homo sapiens	P62993	Anti Tag CoIP	16137687
Intra	TNK2	Q07912	AQP1	Homo sapiens	P29972	Y2H Array	25416956
Intra	TNK2	Q07912	GRB2	Homo sapiens	P62993	Peptide Array	16137687
Intra	TNK2	Q07912	SH2D1A	Homo sapiens	O60880	Validated Y2H	25416956
Intra	TNK2	Q07912	BCAR1	Homo sapiens	P56945	Pull Down	17038317
Intra	TNK2	Q07912	BCAR1	Homo sapiens	P56945	Anti Bait CoIP	17038317
Intra	TNK2	Q07912	NEK6	Homo sapiens	Q9HC98	Validated Y2H	25416956
Intra	TNK2	Q07912	NEK6	Homo sapiens	Q9HC98	Y2H Array	25416956
Intra	TNK2	Q07912	AQP1	Homo sapiens	P29972	Validated Y2H	25416956
Intra	TNK2	Q07912	GALT	Homo sapiens	P07902	Y2H Prey Pooling	25416956
Intra	TNK2	Q07912	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
Intra	TNK2	Q07912	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TNK2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75542	ACK1 Protein, Human (Active, sf9, GST)	Q07912-1 (G110-W476)	≥ 85%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Infantile-Onset Mesial Temporal Lobe Epilepsy With Severe Cognitive Regression
Ductal Carcinoma In Situ	Noninfiltrating Intraductal Carcinoma
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Spinocerebellar Ataxia, Autosomal Recessive 15	Autosomal Recessive Spinocerebellar Ataxia 15 SCAR15 Salih Ataxia Autosomal Recessive Cerebellar Ataxia-Epilepsy-Intellectual Disability Syndrome Due To Rubcn Deficiency Autosomal Recessive Spinocerebellar Ataxia Type 15 Spinocerebellar Ataxia, Autosomal Recessive, 15 Ataxia, Spinocerebellar, Autosomal Recessive, Type 15
Gastric Cardia Carcinoma	Carcinoma Of Cardia Of Stomach
Atypical Chronic Myeloid Leukemia, Bcr-Abl1 Negative	Atypical Chronic Myeloid Leukemia Atypical Chronic Myeloid Leukaemia Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Acml Atypical Chronic Myeloid Leukaemia Bcr-Abl1 Negative Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Atypical Cml Subacute Myeloid Leukemia Subacute Myelogenous Leukaemia Subacute Myeloid Leukaemia Subacute Myelosis Atypical Chronic Myeloid Leukaemia, Bcr-Abl-Negative Without Mention Of Remission Subacute Monocytic Leukaemia Without Mention Of Remission Subacute Monocytic Leukaemia
Immunodeficiency 46	Tfrc-Related Combined Immunodeficiency IMD46 Cid Due To Tfrc Deficiency Combined Immunodeficiency Due To Tfrc Deficiency
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12418	Stenoparib	Inhibitor	98.0%	Phase 2
HY-147245	Basroparib	Inhibitor	98.91%	Phase 1

Pre-clinical Phase

Bioactive Molecules (44)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15147	XAV-939	Inhibitor	99.91%	Unkown
HY-16910	WIKI4	Inhibitor	99.93%	Unkown
HY-13990	NVP-TNKS656		99.68%	Unkown
HY-12438	G007-LK	Inhibitor	99.24%	Unkown
HY-123851	MSC2504877	Inhibitor	99.25%	Unkown
HY-12975	AZ6102	Inhibitor	99.53%	Unkown
HY-148065	FMF-06-098-1	Inhibitor	98.77%	Unkown
HY-15811	XMD8-87	Inhibitor	99.57%	Unkown
HY-19351	MN-64	Inhibitor	99.61%	Unkown
HY-101243	XMD16-5	Inhibitor	98.20%	Unkown
HY-148061	DB1113		99.86%	Unkown
HY-U00422	K-756	Inhibitor	99.25%	Unkown
HY-148063	DB0614		99.92%	Unkown
HY-126248	Tankyrase-IN-2		99.06%	Unkown
HY-147886	PARP1-IN-11	Inhibitor	99.42%	Unkown
HY-121719	TIQ-A	Inhibitor	99.85%	Unkown
HY-156332	TNKS-2-IN-2	Inhibitor	99.47%	Unkown
HY-164478	G-631	Inhibitor	99.88%	Unkown
HY-12577	TNKS1/2-IN-1	Inhibitor	99.24%	Unkown
HY-143338	ART-IN-1	Inhibitor	98.91%	Unkown
HY-146336	PARP1/2/TNKS1/2-IN-1		98.66%	Unkown
HY-173349	TDI-012804	Inhibitor	/	Unkown
HY-23338	TNKS-2-IN-1	Inhibitor	95.03%	Unkown
HY-100847	AZ0108	Inhibitor	/	Unkown
HY-114943	TNKS-IN-1	Inhibitor	99.55%	Unkown
HY-12601	TNKS 22	Inhibitor	/	Unkown
HY-12602	TNKS-IN-4	Inhibitor	/	Unkown
HY-13990G	NVP-TNKS656 (GMP)		/	Unkown
HY-145111	TNK2-IN-1	Inhibitor	/	Unkown
HY-153259	TNKS1/2-IN-2	Inhibitor	/	Unkown
HY-156745	PROTAC DDa-1	Degrader	/	Unkown
HY-167762	TNKS-2-IN-4	Inhibitor	/	Unkown
HY-172747	TNKS-2-IN-3	Inhibitor	/	Unkown
HY-180926	PARP10-IN-4	Inhibitor	/	Unkown
HY-E70868	TNK1 Recombinant Human Active Protein Kinase		/	Unkown
HY-RS14838	TNK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14843	TNKS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14844	Tnks2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14845	TNKS2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-153332	Tankyrase-IN-5	Inhibitor	/	Unkown
HY-168925	EXQ-2d	Inhibitor	/	Unkown
HY-173480	TNKS-IN-3	Inhibitor	/	Unkown
HY-RS16928	Tnk2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23371	Tnk2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TNK2	VGNC	VGNC:66420
Canis familiaris	TNK2	VGNC	VGNC:47680
Bos taurus	TNK2	VGNC	VGNC:36183
Mus musculus	TNK2	MGD	MGI:1858308
Rattus norvegicus	TNK2	RGD	RGD:1305957
Macaca mulatta	TNK2	VGNC	VGNC:79192
Others	TNK2	NCBI