2. Gene
  3. TNK2 - tyrosine kinase non receptor 2 Gene

TNK2 - tyrosine kinase non receptor 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ACK; ACK1; ACK-1; p21cdc42Hs

Gene ID: 10188 | Gene type: protein coding

About TNK2

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:195,863,364-195,908,551 (from NCBI)

This gene has 31 transcripts (splice variants), 153 orthologues, 32 paralogues and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 21.9), bone marrow (RPKM 14.7) and 24 other tissues.

Summary

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 Amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]

TNK2 Products(24)

mRNA Protein Name
NM_001010938.2 NP_001010938.2 activated CDC42 kinase 1 isoform 2
NM_001308046.2 NP_001294975.1 activated CDC42 kinase 1 isoform 3
NM_001382271.1 NP_001369200.1 activated CDC42 kinase 1 isoform 4
NM_001382272.1 NP_001369201.1 activated CDC42 kinase 1 isoform 5
NM_001382273.1 NP_001369202.1 activated CDC42 kinase 1 isoform 6
NM_001382274.1 NP_001369203.1 activated CDC42 kinase 1 isoform 6
NM_001382275.1 NP_001369204.1 activated CDC42 kinase 1 isoform 7
NM_001386164.1 NP_001373093.1 activated CDC42 kinase 1 isoform 8
NM_001387707.1 NP_001374636.1 activated CDC42 kinase 1 isoform 9
NM_001387708.1 NP_001374637.1 activated CDC42 kinase 1 isoform 10
NM_001387709.1 NP_001374638.1 activated CDC42 kinase 1 isoform 8
NM_001387710.1 NP_001374639.1 activated CDC42 kinase 1 isoform 8
NM_001387711.1 NP_001374640.1 activated CDC42 kinase 1 isoform 8
NM_001387712.1 NP_001374641.1 activated CDC42 kinase 1 isoform 8
NM_001387713.1 NP_001374642.1 activated CDC42 kinase 1 isoform 1
NM_001387714.1 NP_001374643.1 activated CDC42 kinase 1 isoform 1
NM_001387715.1 NP_001374644.1 activated CDC42 kinase 1 isoform 11
NM_001387716.1 NP_001374645.1 activated CDC42 kinase 1 isoform 12
NM_001387717.1 NP_001374646.1 activated CDC42 kinase 1 isoform 12
NM_001387718.1 NP_001374647.1 activated CDC42 kinase 1 isoform 12
NM_001387719.1 NP_001374648.1 activated CDC42 kinase 1 isoform 13
NM_001387720.1 NP_001374649.1 activated CDC42 kinase 1 isoform 13
NM_001387721.1 NP_001374650.1 activated CDC42 kinase 1 isoform 13
NM_005781.5 NP_005772.3 activated CDC42 kinase 1 isoform 1

TNK2 Protein Structure

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (126 - 384)

SH3_9

SH3_9: Variant SH3 domain (395 - 444)

GTPase_binding

GTPase_binding: GTPase binding (447 - 514)

Inhibitor_Mig-6

Inhibitor_Mig-6: EGFR receptor inhibitor Mig-6 (774 - 840)

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  • 1038 a.a.
Protein Preferred Names Protein Names

activated CDC42 kinase 1

activated Cdc42-associated kinase 1

Recombinant TNK2 Proteins

Cat. No. Product Name Accession Purity
HY-P75542 ACK1 Protein, Human (sf9, GST) Q07912-1 (G110-W476) ≥95%

Related Diseases

Diseases Alias
Infantile-Onset Mesial Temporal Lobe Epilepsy With Severe Cognitive Regression
Ductal Carcinoma In Situ

Noninfiltrating Intraductal Carcinoma
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
Spinocerebellar Ataxia, Autosomal Recessive 15

Autosomal Recessive Spinocerebellar Ataxia 15

SCAR15

Salih Ataxia

Autosomal Recessive Cerebellar Ataxia-Epilepsy-Intellectual Disability Syndrome Due To Rubcn Deficiency

Autosomal Recessive Spinocerebellar Ataxia Type 15

Spinocerebellar Ataxia, Autosomal Recessive, 15

Ataxia, Spinocerebellar, Autosomal Recessive, Type 15
Gastric Cardia Carcinoma

Carcinoma Of Cardia Of Stomach
Atypical Chronic Myeloid Leukemia, Bcr-Abl1 Negative

Atypical Chronic Myeloid Leukemia

Atypical Chronic Myeloid Leukaemia

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Acml

Atypical Chronic Myeloid Leukaemia Bcr-Abl1 Negative

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Atypical Cml

Subacute Myeloid Leukemia

Subacute Myelogenous Leukaemia

Subacute Myeloid Leukaemia

Subacute Myelosis

Atypical Chronic Myeloid Leukaemia, Bcr-Abl-Negative Without Mention Of Remission

Subacute Monocytic Leukaemia Without Mention Of Remission

Subacute Monocytic Leukaemia
Immunodeficiency 46

Tfrc-Related Combined Immunodeficiency

IMD46

Cid Due To Tfrc Deficiency

Combined Immunodeficiency Due To Tfrc Deficiency
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-12418 Stenoparib Inhibitor ≥98.0% Phase 2
Pre-clinical Phase
Bioactive Molecules (26)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15147 XAV-939 Inhibitor 99.91% Unkown
HY-12438 G007-LK Inhibitor 99.42% Unkown
HY-13990 NVP-TNKS656 99.66% Unkown
HY-12975 AZ6102 Inhibitor 99.65% Unkown
HY-16910 WIKI4 Inhibitor 99.93% Unkown
HY-19351 MN-64 Inhibitor 99.73% Unkown
HY-U00422 K-756 Inhibitor 99.76% Unkown
HY-101243 XMD16-5 Inhibitor 98.59% Unkown
HY-123851 MSC2504877 Inhibitor 98.50% Unkown
HY-15811 XMD8-87 Inhibitor 98.63% Unkown
HY-121719 TIQ-A Inhibitor 99.65% Unkown
HY-143338 ART-IN-1 Inhibitor 98.91% Unkown
HY-148061 DB1113 99.28% Unkown
HY-147886 PARP1-IN-11 Inhibitor 98.58% Unkown
HY-126248 Tankyrase-IN-2 Inhibitor 99.60% Unkown
HY-145111 TNK2-IN-1 Inhibitor / Unkown
HY-146336 PARP1/2/TNKS1/2-IN-1 / Unkown
HY-148065 FMF-06-098-1 / Unkown
HY-153259 TNKS1/2-IN-2 Inhibitor / Unkown
HY-156332 TNKS-2-IN-2 Inhibitor / Unkown
HY-23338 TNKS-2-IN-1 Inhibitor 95.77% Unkown
HY-RS14838 TNK2 Human Pre-designed siRNA Set A / Unkown
HY-RS14843 TNKS2 Human Pre-designed siRNA Set A / Unkown
HY-RS14844 Tnks2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS14845 TNKS2 Rat Pre-designed siRNA Set A / Unkown
HY-153332 Tankyrase-IN-5 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TNK2 VGNC VGNC:66420
Canis familiaris TNK2 VGNC VGNC:47680
Bos taurus TNK2 VGNC VGNC:36183
Mus musculus TNK2 MGD MGI:1858308
Rattus norvegicus TNK2 RGD RGD:1305957
Macaca mulatta TNK2 VGNC VGNC:79192
Others TNK2 NCBI