Nf2 - neurofibromin 2 Gene

Also Known as merlin

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18016

Summary

Predicted to enable beta-catenin binding activity; Integrin binding activity; and protein domain specific binding activity. Involved in lens fiber cell differentiation. Acts upstream of or within several processes, including negative regulation of MAPK cascade; negative regulation of protein kinase activity; and nervous system development. Located in several cellular components, including adherens junction; cleavage furrow; and ruffle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study familial meningioma; neurofibromatosis; otitis media; and renal cell carcinoma. Human ortholog(s) of this gene implicated in familial meningioma; neurilemmomatosis; and neurofibromatosis 2. Orthologous to human NF2 (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor). [provided by Alliance of Genome Resources, Apr 2022]

Nf2 Products (8)

mRNA Protein Name
NM_001252250.1 NP_001239179.1 merlin isoform 1
NM_001252251.1 NP_001239180.1 merlin isoform 1
NM_001252252.1 NP_001239181.1 merlin isoform 3
NM_001252253.1 NP_001239182.1 merlin isoform 4
NM_001361675.1 NP_001348604.1 merlin isoform 5
NM_001361676.1 NP_001348605.1 merlin isoform 6
NM_001361677.1 NP_001348606.1 merlin isoform 7
NM_010898.4 NP_035028.2 merlin isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12695331 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of MAPK cascade IMP
IMP: Inferred from mutant phenotype
16405865 MGI
acts upstream of Schwann cell proliferation IMP
IMP: Inferred from mutant phenotype
10887156 MGI
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
23863479 MGI
acts upstream of or within cell-cell junction organization IMP
IMP: Inferred from mutant phenotype
12695331 MGI
acts upstream of or within ectoderm development IMP
IMP: Inferred from mutant phenotype
9171370 MGI
acts upstream of or within hippocampus development IMP
IMP: Inferred from mutant phenotype
23863479 MGI
involved in lens fiber cell differentiation IMP
IMP: Inferred from mutant phenotype
20181838 MGI
acts upstream of or within mesoderm formation IMP
IMP: Inferred from mutant phenotype
9171370 MGI
acts upstream of or within negative regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
16405865 MGI
acts upstream of or within negative regulation of Schwann cell proliferation IMP
IMP: Inferred from mutant phenotype
10887156 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
9553042 MGI
acts upstream of or within negative regulation of osteoblast proliferation IMP
IMP: Inferred from mutant phenotype
10887156 MGI
acts upstream of or within negative regulation of protein kinase activity IDA
IDA: Inferred from direct assay
14580336 MGI
acts upstream of or within negative regulation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
16405865 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IMP
IMP: Inferred from mutant phenotype
10887156 MGI
acts upstream of osteoblast proliferation IMP
IMP: Inferred from mutant phenotype
10887156 MGI
acts upstream of or within positive regulation of cell differentiation IMP
IMP: Inferred from mutant phenotype
23863479 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
12695331 MGI
acts upstream of or within regulation of gliogenesis IMP
IMP: Inferred from mutant phenotype
25433207 MGI
acts upstream of or within regulation of neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
23863479 MGI
acts upstream of or within regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
25433207 MGI
acts upstream of or within regulation of protein localization to nucleus IMP
IMP: Inferred from mutant phenotype
23863479 MGI
acts upstream of or within regulation of protein stability IMP
IMP: Inferred from mutant phenotype
23863479 MGI
acts upstream of or within regulation of stem cell proliferation IGI
IGI: Inferred from genetic interaction
25433207 MGI
acts upstream of or within regulation of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
25433207 MGI
Cellular Component GO Annotation Evidence References Source
located in adherens junction IMP
IMP: Inferred from mutant phenotype
12695331 MGI
located in apical part of cell IDA
IDA: Inferred from direct assay
23863479 MGI
located in cell body IDA
IDA: Inferred from direct assay
25433207 MGI
located in cleavage furrow IDA
IDA: Inferred from direct assay
9631655 MGI
located in cortical actin cytoskeleton IDA
IDA: Inferred from direct assay
15467741 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
8547603 MGI
located in cytoskeleton IDA
IDA: Inferred from direct assay
15467741 MGI
located in filopodium IDA
IDA: Inferred from direct assay
9563848 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
9563848 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
25433207 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15133494 MGI
located in ruffle IDA
IDA: Inferred from direct assay
9563848 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

merlin

  • moesin-ezrin-radixin-like protein

  • neurofibromatosis 2

  • schwannomin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-400902 VT3989 99.61% Unkown
HY-134955 VT103 Inhibitor 99.64% Unkown
HY-158342 PROTAC TEAD degrader-1 Degrader 99.82% Unkown
HY-163644 VT-105 Inhibitor 99.93% Unkown
HY-155309 LM-41 Inhibitor 99.87% Unkown
HY-155310 AF-2112 Inhibitor 99.82% Unkown
HY-113821 1-Naphthyl phosphate potassium salt Inhibitor 99.86% Unkown
HY-162012 HC-258 / Unkown
HY-181532 IAP ligand 8 Ligand / Unkown
HY-182672 VT101 Inhibitor / Unkown
HY-183728 LC-TEAD01 Inhibitor / Unkown
HY-RS09234 NF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181607 TEAD ligand-Linker Conjugate 3 Degrader / Unkown
HY-RS16884 Nf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23326 Nf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nf2 NCBI NCBI:4771