Nfe2l1 - nuclear factor, erythroid derived 2,-like 1 Gene

Also Known as NRF1; Lcrf1; TCF11; LCR-F1; TCF-11

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18023

Summary

This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases from the use of NRF1 for this gene, NFE2L1, and for "nuclear respiratory factor 1" which has an official symbol of NRF1. [provided by RefSeq, Jul 2008]

Nfe2l1 Products (7)

mRNA Protein Name
NM_001130450.1 NP_001123922.1 endoplasmic reticulum membrane sensor NFE2L1 isoform 1
NM_001130451.1 NP_001123923.1 endoplasmic reticulum membrane sensor NFE2L1 isoform 2
NM_001130452.1 NP_001123924.1 endoplasmic reticulum membrane sensor NFE2L1 isoform 2
NM_001130453.1 NP_001123925.1 endoplasmic reticulum membrane sensor NFE2L1 isoform 3
NM_001130454.1 NP_001123926.1 endoplasmic reticulum membrane sensor NFE2L1 isoform 4
NM_001361682.1 NP_001348611.1 endoplasmic reticulum membrane sensor NFE2L1 isoform 5
NM_008686.3 NP_032712.2 endoplasmic reticulum membrane sensor NFE2L1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
10037736 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
22586274 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
29149604 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10037736 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
22586274 MGI
enables cholesterol binding IDA
IDA: Inferred from direct assay
29149604 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
25637874 MGI
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
25637874 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11342101 MGI
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
16581765 MGI
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
16581765 MGI
Biological Process GO Annotation Evidence References Source
involved in cell redox homeostasis IDA
IDA: Inferred from direct assay
10601325 MGI
acts upstream of or within cellular homeostasis IMP
IMP: Inferred from mutant phenotype
29400713 MGI
involved in cellular response to cholesterol IDA
IDA: Inferred from direct assay
29149604 MGI
acts upstream of or within cellular response to cholesterol IMP
IMP: Inferred from mutant phenotype
29149604 MGI
acts upstream of or within cellular response to cold IMP
IMP: Inferred from mutant phenotype
29400713 MGI
acts upstream of or within cellular response to copper ion IMP
IMP: Inferred from mutant phenotype
24462598 MGI
involved in cellular response to oxidative stress IDA
IDA: Inferred from direct assay
10601325 MGI
involved in cholesterol homeostasis IDA
IDA: Inferred from direct assay
29149604 MGI
acts upstream of or within cholesterol homeostasis IMP
IMP: Inferred from mutant phenotype
29149604 MGI
acts upstream of or within cysteine transport IMP
IMP: Inferred from mutant phenotype
25092871 MGI
acts upstream of or within erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
9501099 MGI
acts upstream of or within fructose 6-phosphate metabolic process IMP
IMP: Inferred from mutant phenotype
25041126 MGI
acts upstream of or within glial cell fate commitment IDA
IDA: Inferred from direct assay
23840004 MGI
acts upstream of or within glucose 6-phosphate metabolic process IMP
IMP: Inferred from mutant phenotype
25041126 MGI
acts upstream of or within glutathione metabolic process IMP
IMP: Inferred from mutant phenotype
25092871 MGI
involved in lipid homeostasis IMP
IMP: Inferred from mutant phenotype
22586274 MGI
acts upstream of or within mitotic metaphase IMP
IMP: Inferred from mutant phenotype
22971132 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10037736 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
24462598 MGI
acts upstream of or within protein polyubiquitination IMP
IMP: Inferred from mutant phenotype
21554501 MGI
acts upstream of or within regulation of fatty acid metabolic process IMP
IMP: Inferred from mutant phenotype
25092871 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
25041126 MGI
acts upstream of or within regulation of glucose metabolic process IMP
IMP: Inferred from mutant phenotype
25041126 MGI
acts upstream of or within regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
29149604 MGI
acts upstream of or within regulation of lipid metabolic process IMP
IMP: Inferred from mutant phenotype
25092871 MGI
acts upstream of or within regulation of mitotic nuclear division IMP
IMP: Inferred from mutant phenotype
22971132 MGI
acts upstream of or within regulation of nucleus organization IMP
IMP: Inferred from mutant phenotype
22971132 MGI
acts upstream of or within regulation of proteasomal protein catabolic process IMP
IMP: Inferred from mutant phenotype
27920251 MGI
acts upstream of or within regulation of response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
29400713 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
25637874 MGI
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20385086 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22971132 MGI
acts upstream of or within response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
25637874 MGI
acts upstream of or within response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
23702335 MGI
acts upstream of or within spinal cord motor neuron differentiation IMP
IMP: Inferred from mutant phenotype
21554501 MGI
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
29400713 MGI
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
25290918 MGI
located in nucleus IDA
IDA: Inferred from direct assay
29149604 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
16581765 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

endoplasmic reticulum membrane sensor NFE2L1

  • NF-E2-related factor 1

  • NFE2-related factor 1

  • locus control region-factor 1

  • nuclear factor erythroid 2-related factor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-178997 NFE2L1 activator-1 98.93% Unkown
HY-RS09244 NFE2L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21165 Nfe2l1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27681 Nfe2l1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nfe2l1 NCBI NCBI:4779