DPYS - dihydropyrimidinase Gene

Also Known as DHP; DHPase

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1807

About DPYS

Cytogenetic location: 8q22.3 Genomic coordinates (GRCh38): 8:104,379,431-104,467,055 (from NCBI)

This gene has 8 transcripts (splice variants), 205 orthologues, 5 paralogues and is associated with 2 phenotypes. Biased expression in liver (RPKM 34.3) and kidney (RPKM 29.7).

Summary

Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008]

DPYS Products (1)

mRNA Protein Name
NM_001385.3 NP_001376.1 dihydropyrimidinase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables dihydropyrimidinase activity IDA
IDA: Inferred from direct assay
9718352 GOA
enables dihydropyrimidinase activity IMP
IMP: Inferred from mutant phenotype
18075467 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in pyrimidine nucleobase catabolic process IDA
IDA: Inferred from direct assay
9718352 GOA
involved in uracil catabolic process IDA
IDA: Inferred from direct assay
10410956 GOA
involved in uracil catabolic process IMP
IMP: Inferred from mutant phenotype
18075467 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DPYS Protein Structure

Amidohydro_1

Amidohydro_1: Amidohydrolase family (59 - 407)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 519 a.a.
Protein Preferred Names Protein Names

dihydropyrimidinase

  • dihydropyrimidine amidohydrolase

DPYS Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DPYS Q14117 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
DPYS Q14117 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
DPYS Q14117 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
DPYS Q14117 HRAS Homo sapiens P01112
Validated Y2H
32814053
Intra
DPYS Q14117 HRAS Homo sapiens P01112
Y2H Array
32814053
Intra
DPYS Q14117 HRAS Homo sapiens P01112
Y2H Pooling
32814053
Intra
DPYS Q14117 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
DPYS Q14117 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
DPYS Q14117 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
DPYS Q14117 APPBP2 Homo sapiens Q92624
Validated Y2H
32296183
Intra
DPYS Q14117 APPBP2 Homo sapiens Q92624
Y2H Array
32296183
Intra
DPYS Q14117 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DPYS Proteins

Cat. No. Product Name Accession Purity
HY-P75713 DPYS Protein, Human (sf9) Q14117 (N-G&P, M1-P519) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75714 DPYS Protein, Human (sf9, His-GST) Q14117 (M1-P519) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Dihydropyrimidinase Deficiency

  • Dihydropyrimidinuria

  • Dpys Deficiency

  • Dph Deficiency

  • DPYSD

  • Dihydrouracil Amidohydrolase Deficiency

  • Dihydropyrimidinuria Due To Dpys Deficiency
Dihydropyrimidine Dehydrogenase Deficiency

  • Dpd Deficiency

  • Familial Pyrimidinemia

  • Hereditary Thymine-Uraciluria

  • Dihydropyrimidinuria

  • Dpyd Deficiency

  • Thymine-Uraciluria, Hereditary

  • Pyrimidinemia, Familial

  • 5-Fluorouracil Toxicity

  • Dihydrouracil Dehydrogenase Deficiency

  • Familial Pyrimidinaemia

  • Thymine-Uracilurea

  • Familial Pyrimidemia

  • Pyrimidinemia Familial

  • DPYDD
Pyrimidine Metabolic Disorder

  • Disorder Of Pyrimidine Metabolism

  • Pyrimidine Metabolism Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03976 DPY19L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03977 DPY19L3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03978 DPY30 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03980 DPYS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20718 Dpys Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20912 Dpy30 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27229 Dpys Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27429 Dpy30 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27430 Duox2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris DPYS VGNC VGNC:40082
Mus musculus DPYS MGD MGI:1928679
Bos taurus DPYS VGNC VGNC:28194
Macaca mulatta DPYS VGNC VGNC:71983
Felis catus DPYS VGNC VGNC:61614
Rattus norvegicus DPYS RGD RGD:68376
Others DPYS NCBI