Pde1c - phosphodiesterase 1C Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18575

Summary

Predicted to enable cAMP binding activity; calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; and calmodulin-dependent cyclic-nucleotide phosphodiesterase activity. Acts upstream of or within sensory perception of smell. Located in cilium. Is expressed in several structures, including alimentary system; integumental system; male reproductive gland or organ; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 74. Orthologous to human PDE1C (phosphodiesterase 1C). [provided by Alliance of Genome Resources, Apr 2022]

Pde1c Products (15)

mRNA Protein Name
NM_001025568.3 NP_001020739.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform b
NM_001159952.2 NP_001153424.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform c
NM_001159953.2 NP_001153425.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform d
NM_001159955.2 NP_001153427.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform a
NM_001159956.2 NP_001153428.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform f
NM_001159957.2 NP_001153429.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform e
NM_001159960.2 NP_001153432.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform b
NM_001355475.2 NP_001342404.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform a
NM_001410253.1 NP_001397182.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform b
NM_001410254.1 NP_001397183.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform b
NM_001410255.1 NP_001397184.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform g
NM_001410256.1 NP_001397185.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform h
NM_001410257.1 NP_001397186.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform i
NM_001410258.1 NP_001397187.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform j
NM_011054.5 NP_035184.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
8810348 MGI
enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
8810348 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within sensory perception of smell IGI
IGI: Inferred from genetic interaction
19305400 MGI
acts upstream of or within sensory perception of smell IMP
IMP: Inferred from mutant phenotype
19305400 MGI
Cellular Component GO Annotation Evidence References Source
located in cilium IDA
IDA: Inferred from direct assay
19305400 MGI
located in lysosome IDA
IDA: Inferred from direct assay
29860631 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

  • 3',5'-cyclic-AMP phosphodiesterase

  • 3',5'-cyclic-GMP phosphodiesterase

  • cam-PDE 1C

  • dual specificity Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-12501A ITI-214 Inhibitor 99.56% Phase 2
HY-112831 Osoresnontrine Inhibitor 99.94% Phase 2

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101490 PDE1-IN-2 Inhibitor 98.0% Unkown
HY-169402 PDE1-IN-9 Inhibitor / Unkown
HY-169402A PDE1-IN-9 hydrochloride Inhibitor / Unkown
HY-12501 ITI-214 free base Inhibitor 98.0% Unkown
HY-120741 PF-04822163 Inhibitor / Unkown
HY-120195 PF-04677490 Inhibitor / Unkown
HY-120195A PF-04827736 Inhibitor / Unkown
HY-147946 PDE1-IN-4 Inhibitor / Unkown
HY-155199 PDE1-IN-5 Inhibitor / Unkown
HY-RS10212 PDE1C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N11262 Sudachitin / Unkown
HY-RS19228 Pde1c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25717 Pde1c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-U00374 Sch59498 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde1c NCBI NCBI:5137