Pde8a - phosphodiesterase 8A Gene

Also Known as Pde8

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18584

About Pde8a

Chromosome 7: 80,863,344-80,984,281 forward strand.GRCm39:CM001000.3

This gene has 3 transcripts (splice variants), 220 orthologues, 20 paralogues and is associated with 8 phenotypes. Broad expression in testis adult (RPKM 48.2), kidney adult (RPKM 13.7) and 18 other tissues.

Summary

Enables 3',5'-cyclic-AMP phosphodiesterase activity. Involved in cellular response to epidermal growth factor stimulus and positive regulation of ERK1 and ERK2 cascade. Is expressed in several structures, including genitourinary system; gut gland; integumental system; nervous system; and skeleton. Orthologous to human PDE8A (phosphodiesterase 8A). [provided by Alliance of Genome Resources, Apr 2022]

Pde8a Products (1)

mRNA Protein Name
NM_008803.3 NP_032829.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

Pde8a Protein Structure

OmpR

OmpR: cl34028 (77 - 154)

PAS

PAS: COG2202 (117 - 319)

PAS_9

PAS_9: pfam13426 (221 - 319)

PDEase_I

PDEase_I: pfam00233 (549 - 799)

  • 0
  • 200
  • 400
  • 600
  • 823 a.a.
Protein Preferred Names Protein Names

high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15426 PF-04957325 Inhibitor 99.55% Unkown
HY-134937 BC8-15 Inhibitor / Unkown
HY-179503 PDE/TRPA1/CHIT1-IN-1 Inhibitor / Unkown
HY-RS10242 PDE8A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10243 Pde8a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10244 Pde8a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde8a NCBI NCBI:5151