Cdk14 - cyclin-dependent kinase 14 Gene

Also Known as Pftk1; mKIAA0834

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18647

About Cdk14

Chromosome 5: 4,853,391-5,470,312 reverse strand.GRCm39:CM000998.3

This gene has 15 transcripts (splice variants), 201 orthologues, 25 paralogues and is associated with 2 phenotypes. Biased expression in frontal lobe adult (RPKM 18.7), cortex adult (RPKM 14.) and 13 other tissues.

Summary

Enables protein kinase activity. Predicted to be involved in mitotic cell cycle phase transition; protein phosphorylation; and regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within Wnt signaling pathway; cell division; and phosphorylation. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human CDK14 (cyclin dependent kinase 14). [provided by Alliance of Genome Resources, Apr 2022]

Cdk14 Products (2)

mRNA Protein Name
NM_001310448.1 NP_001297377.1 cyclin-dependent kinase 14 isoform 2
NM_011074.3 NP_035204.2 cyclin-dependent kinase 14 isoform 1

Cdk14 Protein Structure

STKc_PFTAIRE1

STKc_PFTAIRE1: cd07869 (128 - 430)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 469 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 14

  • cell division protein kinase 14

  • serine/threonine-protein kinase PFTAIRE-1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-X0009 Tambiciclib Inhibitor 99.68% Phase 2

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-127104 FMF-04-159-2 Inhibitor 99.64% Unkown
HY-X0150 JSH-150 Inhibitor 98.36% Unkown
HY-137342 SB1-G-187 Degrader 98.70% Unkown
HY-X0009A Tambiciclib dimaleate Inhibitor 99.53% Unkown
HY-160213 JA397 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk14 NCBI NCBI:5218