Pik3cd - phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Gene

Also Known as p110delta; 2410099E07Rik; 2610208K16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18707

About Pik3cd

Chromosome 4: 149,733,625-149,787,028 reverse strand.GRCm39:CM000997.3

This gene has 14 transcripts (splice variants), 214 orthologues, 9 paralogues and is associated with 40 phenotypes. Broad expression in spleen adult (RPKM 42.3), thymus adult (RPKM 28.3) and 18 other tissues.

Summary

Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in positive regulation of angiogenesis and positive regulation of protein kinase B signaling. Acts upstream of or within several processes, including B cell activation; B cell homeostasis; and defense response to fungus. Predicted to be located in cytosol. Predicted to be part of phosphatidylinositol 3-kinase complex. Predicted to be active in cytoplasm and plasma membrane. Is expressed in early embryo; hemolymphoid system; nervous system; sensory organ; and testis. Human ortholog(s) of this gene implicated in colorectal cancer; endometrial cancer; and immunodeficiency 14. Orthologous to human PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta). [provided by Alliance of Genome Resources, Apr 2022]

Pik3cd Products (6)

mRNA Protein Name
NM_001164049.1 NP_001157521.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform b
NM_008840.3 NP_032866.2 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform c
NM_001029837.2 NP_001025008.2 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform b
NM_001164051.1 NP_001157523.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform e
NM_001164052.1 NP_001157524.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform a
NM_001164050.1 NP_001157522.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform d

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22020336 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell activation IMP
IMP: Inferred from mutant phenotype
12235209 MGI
acts upstream of or within B cell homeostasis IMP
IMP: Inferred from mutant phenotype
12235209 MGI
acts upstream of or within cell surface receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12235209 MGI
acts upstream of or within defense response to fungus IMP
IMP: Inferred from mutant phenotype
24009720 MGI
acts upstream of or within homeostasis of number of cells IMP
IMP: Inferred from mutant phenotype
24009720 MGI
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
31915155 MGI
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
31915155 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
24009720 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pik3cd Protein Structure

PI3K_p85B

PI3K_p85B: pfam02192 (31 - 106)

PI3K_rbd

PI3K_rbd: pfam00794 (181 - 280)

C2_PI3K_class_I_beta_delta

C2_PI3K_class_I_beta_delta: cd08693 (313 - 480)

PI3Ka

PI3Ka: smart00145 (504 - 682)

PI3Kc_IA_delta

PI3Kc_IA_delta: cd05174 (674 - 1040)

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  • 1043 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

  • PI3-kinase subunit delta

  • PI3K-delta

  • PI3Kdelta

  • catalytic phosphatidylinositol 3-kinase delta

  • p100 delta

  • phosphatidylinositol 3-kinase catalytic delta polypeptide

  • phosphatidylinositol 3-kinase catalytic subunit delta

  • phosphatidylinositol 3-kinase p110 delta

  • phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta

  • phosphoinositide 3 kinase P110delta

  • ptdIns-3-kinase subunit delta

  • ptdIns-3-kinase subunit p110-delta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-161366 OMS14 Inhibitor 99.09% Unkown
HY-RS02840 CLSTN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10529 PIK3CD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10530 Pik3cd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10531 Pik3cd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pik3cd NCBI NCBI:5293