Prkca - protein kinase C, alpha Gene

Also Known as Pkca

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18750

About Prkca

Chromosome 11: 107,824,213-108,234,754 reverse strand.GRCm39:CM001004.3

This gene has 4 transcripts (splice variants), 284 orthologues, 9 paralogues and is associated with 8 phenotypes. Broad expression in frontal lobe adult (RPKM 19.9), cortex adult (RPKM 11.1) and 22 other tissues.

Summary

Enables calcium-dependent protein kinase C activity and Integrin binding activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of bone resorption; and positive regulation of dense core granule biogenesis. Acts upstream of or within several processes, including induction of positive chemotaxis; negative regulation of signal transduction; and regulation of protein phosphorylation. Located in several cellular components, including calyx of Held; intercalated disc; and photoreceptor outer segment. Part of alphav-beta3 integrin-PKCalpha complex. Is active in presynaptic cytosol. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; high grade glioma (multiple); large cell carcinoma; and reproductive organ Cancer (multiple). Orthologous to human PRKCA (protein kinase C alpha). [provided by Alliance of Genome Resources, Apr 2022]

Prkca Products (1)

mRNA Protein Name
NM_011101.3 NP_035231.2 protein kinase C alpha type

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium,diacylglycerol-dependent serine/threonine kinase activity IDA
IDA: Inferred from direct assay
7741753 MGI
enables calcium,diacylglycerol-dependent serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
7828597 MGI
enables diacylglycerol-dependent serine/threonine kinase activity IDA
IDA: Inferred from direct assay
12618484 MGI
enables integrin binding IPI
IPI: Inferred from physical interaction
16014375 MGI
enables lipid binding EXP
EXP: Inferred from Experiment
23762412 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12618484 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
14966518 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
17956267 MGI
acts upstream of or within cellular response to carbohydrate stimulus IDA
IDA: Inferred from direct assay
16585392 MGI
acts upstream of or within chondrocyte differentiation IDA
IDA: Inferred from direct assay
17644814 MGI
acts upstream of or within induction of positive chemotaxis IMP
IMP: Inferred from mutant phenotype
12928424 MGI
acts upstream of or within intracellular calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
14966518 MGI
acts upstream of or within intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
12928424 MGI
acts upstream of or within muscle cell cellular homeostasis IMP
IMP: Inferred from mutant phenotype
14966518 MGI
acts upstream of or within negative regulation of D-glucose import IMP
IMP: Inferred from mutant phenotype
11923480 MGI
acts upstream of or within negative regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
11923480 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
17956267 MGI
acts upstream of or within negative regulation of insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
11923480 MGI
acts upstream of or within negative regulation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
11923480 MGI
acts upstream of or within negative regulation of protein phosphorylation IGI
IGI: Inferred from genetic interaction
24305805 MGI
acts upstream of or within negative regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
14966518 MGI
acts upstream of or within neutrophil chemotaxis IMP
IMP: Inferred from mutant phenotype
12928424 MGI
acts upstream of or within peptidyl-serine autophosphorylation IDA
IDA: Inferred from direct assay
16814779 MGI
involved in positive regulation of bone resorption IMP
IMP: Inferred from mutant phenotype
16014375 MGI
involved in positive regulation of dense core granule biogenesis IMP
IMP: Inferred from mutant phenotype
19147982 MGI
acts upstream of or within positive regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
12928424 MGI
involved in positive regulation of macrophage differentiation IMP
IMP: Inferred from mutant phenotype
9508782 MGI
acts upstream of or within positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
14966518 MGI
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
21658591 MGI
involved in presynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
21658591 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
7741753 MGI
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
31578312 MGI
acts upstream of protein phosphorylation IGI
IGI: Inferred from genetic interaction
24305805 MGI
acts upstream of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
14966518 MGI
acts upstream of or within regulation of muscle contraction IMP
IMP: Inferred from mutant phenotype
14966518 MGI
acts upstream of or within regulation of peptidyl-tyrosine phosphorylation IMP
IMP: Inferred from mutant phenotype
11940581 MGI
involved in regulation of platelet aggregation IMP
IMP: Inferred from mutant phenotype
19147982 MGI
involved in regulation of synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
21658591 MGI
involved in regulation of synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
21658591 MGI
acts upstream of or within regulation of the force of heart contraction IMP
IMP: Inferred from mutant phenotype
14966518 MGI
acts upstream of or within stem cell differentiation IDA
IDA: Inferred from direct assay
17644814 MGI
Cellular Component GO Annotation Evidence References Source
part of alphav-beta3 integrin-PKCalpha complex IDA
IDA: Inferred from direct assay
16014375 MGI
located in apical part of cell IDA
IDA: Inferred from direct assay
23863479 MGI
located in axon IDA
IDA: Inferred from direct assay
18265009 MGI
is active in calyx of Held IDA
IDA: Inferred from direct assay
21658591 MGI
is active in calyx of Held IMP
IMP: Inferred from mutant phenotype
21658591 MGI
located in cone photoreceptor outer segment IDA
IDA: Inferred from direct assay
10813773 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
10882525 MGI
located in dendrite IDA
IDA: Inferred from direct assay
12115694 MGI
located in intercalated disc IDA
IDA: Inferred from direct assay
27353086 MGI
located in membrane IDA
IDA: Inferred from direct assay
18323529 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
12826667 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
12115694 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10882525 MGI
located in ooplasm IDA
IDA: Inferred from direct assay
15590069 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10882525 MGI
is active in presynaptic cytosol IDA
IDA: Inferred from direct assay
21658591 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
27353086 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkca Protein Structure

C1_cPKC_rpt1

C1_cPKC_rpt1: cd20833 (34 - 91)

C1_cPKC_rpt2

C1_cPKC_rpt2: cd20836 (101 - 154)

C2_PKC_alpha_gamma

C2_PKC_alpha_gamma: cd04026 (158 - 288)

STKc_cPKC_alpha

STKc_cPKC_alpha: cd05615 (327 - 667)

  • 0
  • 200
  • 400
  • 600
  • 672 a.a.
Protein Preferred Names Protein Names

protein kinase C alpha type

  • PKC-A

  • PKC-alpha

  • protein kinase c-alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11116 PRKCA Human Pre-designed siRNA Set A / Unkown
HY-RS11117 Prkca Mouse Pre-designed siRNA Set A / Unkown
HY-RS11118 Prkca Rat Pre-designed siRNA Set A / Unkown
HY-174543 Human PRKCA mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prkca NCBI NCBI:5578