Pklr - pyruvate kinase liver and red blood cell Gene

Also Known as Pk1; Pk-1; R-PK

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18770

Summary

Enables Pyruvate Kinase activity. Acts upstream of or within response to Other organism. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study malaria and Pyruvate Kinase deficiency of red cells. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; malaria; Pyruvate Kinase deficiency of red cells; and type 2 diabetes mellitus. Orthologous to human PKLR (Pyruvate Kinase L/R). [provided by Alliance of Genome Resources, Apr 2022]

Pklr Products (2)

mRNA Protein Name
NM_001099779.1 NP_001093249.1 pyruvate kinase PKLR isoform 2
NM_013631.2 NP_038659.2 pyruvate kinase PKLR isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables pyruvate kinase activity IDA
IDA: Inferred from direct assay
7295297 MGI
Biological Process GO Annotation Evidence References Source
involved in glycolytic process IDA
IDA: Inferred from direct assay
7295297 MGI
acts upstream of or within response to other organism IMP
IMP: Inferred from mutant phenotype
14595440 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18698006 MGI
is active in cytosol IDA
IDA: Inferred from direct assay
30150719 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
18698006 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pyruvate kinase PKLR

  • L-PK

  • pyruvate kinase isozymes L/R

  • pyruvate kinase isozymes R/L

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12689 Mitapivat Activator 99.84% Yes
HY-12689A Mitapivat hemisulfate sesquihydrate Activator / Unkown
HY-12689B Mitapivat hemisulfate Activator / Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-135884 Tebapivat Activator 99.66% Phase 2

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122682 SBI-993 98.79% Unkown
HY-12689S Mitapivat-d8 Activator / Unkown
HY-RS10601 PKLR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18255 Pklr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24735 Pklr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pklr NCBI NCBI:5313