Lypla1 - lysophospholipase 1 Gene

Also Known as APT-1; LPL-I; Pla1a; Gm39587

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18777

Summary

Enables palmitoyl-(protein) hydrolase activity. Involved in protein depalmitoylation. Acts upstream of or within negative regulation of Golgi to plasma membrane protein transport. Located in cytosol. Is expressed in several structures, including brain; cardiovascular system; cranium; genitourinary system; and gut. Orthologous to human LYPLA1 (lysophospholipase 1). [provided by Alliance of Genome Resources, Apr 2022]

Lypla1 Products (2)

mRNA Protein Name
NM_001355712.1 NP_001342641.1 acyl-protein thioesterase 1 isoform 2
NM_008866.3 NP_032892.1 acyl-protein thioesterase 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables palmitoyl-(protein) hydrolase activity IDA
IDA: Inferred from direct assay
27307232 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of Golgi to plasma membrane protein transport IMP
IMP: Inferred from mutant phenotype
22399288 MGI
involved in protein depalmitoylation IDA
IDA: Inferred from direct assay
27307232 MGI
acts upstream of or within protein depalmitoylation IMP
IMP: Inferred from mutant phenotype
22399288 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
22399288 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

acyl-protein thioesterase 1

  • lysoPLA I

  • lysophopholipase 1

  • lysophospholipase I

  • palmitoyl-protein hydrolase

  • phospholipase 1a

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100736 ML348 Inhibitor 99.97% Unkown
HY-128035 ML-211 Inhibitor 99.42% Unkown
HY-129121 ML-​226 Inhibitor 98.76% Unkown
HY-120126 ML378 Inhibitor / Unkown
HY-RS07921 LYPLA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17852 Lypla1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24321 Lypla1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lypla1 NCBI NCBI:10434