GPR183 - G protein-coupled receptor 183 Gene

Also Known as EBI2; hEBI2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1880

About GPR183

Cytogenetic location: 13q32.3 Genomic coordinates (GRCh38): 13:99,294,539-99,307,399 (from NCBI)

This gene has 1 transcript (splice variant), 207 orthologues and 7 paralogues. Broad expression in appendix (RPKM 44.7), bone marrow (RPKM 34.8) and 17 other tissues.

Summary

This gene was identified by the up-regulation of its expression upon Epstein-Barr virus Infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the Thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq, Jul 2008]

GPR183 Products (1)

mRNA	Protein	Name
NM_004951.5	NP_004942.1	G-protein coupled receptor 183

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	18628402	GOA
enables oxysterol binding	IDA IDA: Inferred from direct assay	21796212	GOA
enables oxysterol binding	IMP IMP: Inferred from mutant phenotype	24678947	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	18628402	GOA
involved in leukocyte chemotaxis	IMP IMP: Inferred from mutant phenotype	24678947	GOA
involved in positive regulation of B cell proliferation	IDA IDA: Inferred from direct assay	21673108	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	21673108	GOA
involved in regulation of astrocyte chemotaxis	IDA IDA: Inferred from direct assay	25297897	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	18628402	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR183 Protein Structure

7tm_1

0
100
200
300
361 a.a.

Protein Preferred Names	Protein Names
G-protein coupled receptor 183	EBV-induced G-protein coupled receptor 2 Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor) epstein-Barr virus-induced G-protein coupled receptor 2

Related Diseases

Diseases	Alias
Bile Acid Synthesis Defect, Congenital, 3	Congenital Bile Acid Synthesis Defect 3 CBAS3 Oxysterol 7-Alpha-Hydroxylase Deficiency Congenital Bile Acid Synthesis Defect Type 3 Basd3 Bile Acid Synthesis Defect, Congenital, Type 3
Congenital Bile Acid Synthesis Defect	3-Beta-Hydroxy-Delta-5-C27-Steroid Oxidoreductase Deficiency Cba Cholestasis With Delta(4)-3-Oxosteroid-5-Beta-Reductase Deficiency Basd Bile Acid Synthesis Defect, Congenital, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-175306	GPR183 inverse agonist-1	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-113962	7α,25-Dihydroxycholesterol	Agonist	99.88%	Unkown
HY-162618	PSB-KK1445	Agonist	99.80%	Unkown
HY-147222	SAE-14	Antagonist	98.60%	Unkown
HY-157939	GPR183 antagonist-3	Antagonist	98.79%	Unkown
HY-113962S	7α,25-Dihydroxycholesterol-d6		/	Unkown
HY-RS05690	GPR183 Human Pre-designed siRNA Set A		/	Unkown
HY-RS05691	Gpr183 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS05692	Gpr183 Rat Pre-designed siRNA Set A		/	Unkown
HY-400897	7α,25-Dihydroxycholesterol intermediate-1		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GPR183	VGNC	VGNC:73042
Rattus norvegicus	GPR183	RGD	RGD:1598095
Mus musculus	GPR183	MGD	MGI:2442034
Canis familiaris	GPR183	VGNC	VGNC:41423
Bos taurus	GPR183	VGNC	VGNC:29577
Others	GPR183	NCBI