Pomc - pro-opiomelanocortin-alpha Gene

Also Known as BE; Npp; ACTH; Clip; Pomc1; Pomc-1; Beta-LPH; alphaMSH; beta-MSH; Gamma-LPH; alpha-MSH; gamma-MSH

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18976

Summary

This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing. Processing yields several biologically active peptides, which are involved in diverse cellular functions, such as energy homeostasis, steroidogenesis, and increased melanin production in melanocytes. In mouse deficiency of this gene is associated with obesity, defects in adrenal development, and altered pigmentation. A pseudogene of this gene is located on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Pomc Products (5)

mRNA Protein Name
NM_001278581.1 NP_001265510.1 pro-opiomelanocortin preproprotein
NM_001278582.1 NP_001265511.1 pro-opiomelanocortin preproprotein
NM_001278583.1 NP_001265512.1 pro-opiomelanocortin preproprotein
NM_001278584.1 NP_001265513.1 pro-opiomelanocortin preproprotein
NM_008895.4 NP_032921.1 pro-opiomelanocortin preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables hormone activity IDA
IDA: Inferred from direct assay
15467755 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16219686 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within calcium-mediated signaling IMP
IMP: Inferred from mutant phenotype
25096581 MGI
acts upstream of or within glucose homeostasis IMP
IMP: Inferred from mutant phenotype
21184805 MGI
involved in positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
25096581 MGI
involved in positive regulation of oxytocin production IDA
IDA: Inferred from direct assay
25096581 MGI
acts upstream of or within regulation of blood pressure IGI
IGI: Inferred from genetic interaction
16243970 MGI
acts upstream of or within regulation of corticosterone secretion IMP
IMP: Inferred from mutant phenotype
21184805 MGI
acts upstream of or within regulation of glycogen metabolic process IMP
IMP: Inferred from mutant phenotype
21184805 MGI
involved in response to melanocyte-stimulating hormone IDA
IDA: Inferred from direct assay
25096581 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18388149 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
16219686 MGI
located in secretory granule IDA
IDA: Inferred from direct assay
1329576 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pro-opiomelanocortin

  • adrenal corticotropic hormone

  • adrenocorticotropic hormone

  • alpha-melanocyte stimulating hormone

  • beta-endorphin

  • corticotropin-like intermediary peptide

  • corticotropin-lipotropin

  • melanotropin gamma

  • met-enkephalin

Orthologs Information

Species Symbol Source ID
Homo sapiens Pomc NCBI NCBI:5443