Pparg - peroxisome proliferator activated receptor gamma Gene

Also Known as Nr1c3; PPARgamma; PPAR-gamma; PPARgamma2; PPAR-gamma2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19016

About Pparg

Chromosome 6: 115,337,912-115,467,360 forward strand.GRCm39:CM000999.3

This gene has 7 transcripts (splice variants), 405 orthologues, 19 paralogues and is associated with 144 phenotypes. Biased expression in subcutaneous fat pad adult (RPKM 32.5), mammary gland adult (RPKM 26.1) and 13 other tissues.

Summary

This gene encodes a nuclear receptor protein belonging to the Peroxisome Proliferator-activated Receptor (PPAR) family. The encoded protein is a ligand-activated transcription factor that is involved in the regulation of adipocyte differentiation and glucose homeostasis. The encoded protein forms a heterodimer with retinoid X receptors and binds to DNA motifs termed "peroxisome proliferator response elements" to either activate or inhibit gene expression. Mice lacking the encoded protein die at an embryonic stage due to severe defects in placental vascularization. When the embryos lacking this gene are supplemented with healthy placentas, the mutants survive to term, but succumb to lipodystrophy and multiple hemorrhages. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Pparg Products (5)

mRNA Protein Name
NM_001410262.1 NP_001397191.1 peroxisome proliferator-activated receptor gamma isoform 1
NM_001308354.2 NP_001295283.1 peroxisome proliferator-activated receptor gamma isoform 1
NM_001308352.2 NP_001295281.1 peroxisome proliferator-activated receptor gamma isoform 1
NM_001127330.3 NP_001120802.1 peroxisome proliferator-activated receptor gamma isoform 1
NM_011146.4 NP_035276.2 peroxisome proliferator-activated receptor gamma isoform 2
Protein Preferred Names Protein Names

peroxisome proliferator-activated receptor gamma

  • nuclear receptor subfamily 1 group C member 3

  • peroxisome proliferator activated receptor gamma 2

  • peroxisome proliferator activated receptor gamma 4

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-153344 FX-909 Inhibitor 99.79% Phase 1

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-153364 FTX-6746 Inhibitor 99.07% Unkown
HY-160160 BAY-5516 Inhibitor 98.17% Unkown
HY-W009066 2-Ethylhexyl diphenyl phosphate 96.00% Unkown
HY-108569 nTZDpa 98.53% Unkown
HY-160161 BAY-5094 Inhibitor 98.04% Unkown
HY-RS10925 PPARG Human Pre-designed siRNA Set A / Unkown
HY-RS10926 Pparg Mouse Pre-designed siRNA Set A / Unkown
HY-121579 L-764406 Agonist / Unkown
HY-160159 PPARγ modulator-1 Modulator / Unkown
HY-160188 BAY-9683 Modulator / Unkown
HY-178447 PPARγ agonist 20 / Unkown
HY-RS10927 Pparg Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pparg NCBI NCBI:5468