Ppt1 - palmitoyl-protein thioesterase 1 Gene

Also Known as PPT; CLN1; INCL; D4Ertd184e; 9530043G02Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 19063

Summary

Enables palmitoyl-(protein) hydrolase activity. Acts upstream of or within several processes, including grooming behavior; protein catabolic process; and regulation of Phospholipase A2 activity. Located in several cellular components, including dendrite; lysosome; and neuronal cell body. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study neuronal ceroid lipofuscinosis 1 and neuronal ceroid lipofuscinosis 3. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 1. Orthologous to human PPT1 (palmitoyl-protein thioesterase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ppt1 Products (1)

mRNA	Protein	Name
NM_008917.3	NP_032943.2	palmitoyl-protein thioesterase 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables palmitoyl-(protein) hydrolase activity	IDA IDA: Inferred from direct assay	12483688	MGI
enables palmitoyl-(protein) hydrolase activity	IMP IMP: Inferred from mutant phenotype	11717424	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19941651	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within adult locomotory behavior	IMP IMP: Inferred from mutant phenotype	11717424	MGI
acts upstream of or within associative learning	IMP IMP: Inferred from mutant phenotype	15885820	MGI
acts upstream of or within grooming behavior	IMP IMP: Inferred from mutant phenotype	11717424	MGI
acts upstream of or within lysosome organization	IMP IMP: Inferred from mutant phenotype	16368712	MGI
acts upstream of or within macromolecule catabolic process	IMP IMP: Inferred from mutant phenotype	15647513	MGI
acts upstream of or within neurotransmitter secretion	IMP IMP: Inferred from mutant phenotype	16242638	MGI
acts upstream of or within protein catabolic process	IMP IMP: Inferred from mutant phenotype	16368712	MGI
acts upstream of or within protein depalmitoylation	IMP IMP: Inferred from mutant phenotype	11717424	MGI
acts upstream of or within regulation of phospholipase A2 activity	IMP IMP: Inferred from mutant phenotype	17341491	MGI
acts upstream of or within visual perception	IMP IMP: Inferred from mutant phenotype	15649713	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	12483688	MGI
located in dendrite	IDA IDA: Inferred from direct assay	10611498	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	9685319	MGI
located in lysosome	IDA IDA: Inferred from direct assay	9685319	MGI
located in lysosome	IMP IMP: Inferred from mutant phenotype	16242638	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	10611498	MGI
is active in presynaptic cytosol	IDA IDA: Inferred from direct assay	35358180	MGI
is active in presynaptic cytosol	IEP IEP: Inferred from expression pattern	35358180	MGI
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	18704195	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
palmitoyl-protein thioesterase 1	PPT-1 palmitoyl-protein hydrolase 1

Recombinant Ppt1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700622	PPT1 Protein, Mouse (HEK293, His)	O88531 (D28-K306)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-137978A	Ezurpimtrostat hydrochloride		99.26%	Phase 2
HY-137978	Ezurpimtrostat		99.37%	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111621	DC661		99.53%	Unkown
HY-120252	ABC44	Inhibitor	98.7%	Unkown
HY-170670	DQ661	Inhibitor	/	Unkown
HY-183351	GN-604		/	Unkown
HY-RS11038	PPT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17296	Ppt1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23751	Ppt1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppt1	NCBI	NCBI:5538