Mapk8ip1 - mitogen-activated protein kinase 8 interacting protein 1 Gene

Also Known as IB1; Jip1; Skip; JIP-1; Prkm8ip; mjip-2a

Species: Mus musculus

Gene Type: protein coding

Gene ID: 19099

Summary

Enables Kinesin binding activity and protein kinase binding activity. Involved in positive regulation of JNK cascade and regulation of CD8-positive, alpha-beta T cell proliferation. Acts upstream of or within several processes, including JUN phosphorylation; negative regulation of intrinsic apoptotic signaling pathway; and regulation of transcription, DNA-templated. Located in several cellular components, including cell body; dendrite; and dentate gyrus mossy fiber. Is expressed in intestine smooth muscle circular layer; nervous system; renal vasculature; and sensory organ. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MAPK8IP1 (mitogen-activated protein kinase 8 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Mapk8ip1 Products (3)

mRNA	Protein	Name
NM_001202445.1	NP_001189374.1	C-Jun-amino-terminal kinase-interacting protein 1 isoform 2
NM_001202446.1	NP_001189375.1	C-Jun-amino-terminal kinase-interacting protein 1 isoform 3
NM_011162.5	NP_035292.2	C-Jun-amino-terminal kinase-interacting protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables kinesin binding	IPI IPI: Inferred from physical interaction	11238452	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10827173	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	11562351	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within JUN phosphorylation	IDA IDA: Inferred from direct assay	9235893	MGI
acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	10098834	MGI
involved in positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	23963642	MGI
involved in regulation of CD8-positive, alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	23963642	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9235893	MGI
involved in regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	11562351	MGI
acts upstream of or within signal transduction	IDA IDA: Inferred from direct assay	9235893	MGI
acts upstream of or within vesicle-mediated transport	IDA IDA: Inferred from direct assay	16301330	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	10712642	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	10712642	MGI
located in cytosol	IDA IDA: Inferred from direct assay	10712642	MGI
located in dendrite	IDA IDA: Inferred from direct assay	10712642	MGI
located in dentate gyrus mossy fiber	IDA IDA: Inferred from direct assay	10712642	MGI
located in membrane	IDA IDA: Inferred from direct assay	10712642	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	16301330	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	10712642	MGI
located in synapse	IDA IDA: Inferred from direct assay	10712642	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
C-Jun-amino-terminal kinase-interacting protein 1	IB-1 JNK MAP kinase scaffold protein 1 JNK-interacting protein 1 islet-brain-1 protein kinase, mitogen-activated 8 interacting protein

Mapk8ip1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Mapk8ip1	Q9WVI9	Lrp1	Mus musculus	Q91ZX7	Pull Down	10827173
Intra	Mapk8ip1	Q9WVI9	Lrp1	Mus musculus	Q91ZX7	Y2H	10827173

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08124	MAPK8IP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22065	Mapk8ip1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mapk8ip1	NCBI	NCBI:9479