Pde9a - phosphodiesterase 9A Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 191569

About Pde9a

Primary_assembly 20: 9,469,848-9,562,948 forward strand.mRatBN7.2:CM026993.1

This gene has 5 transcripts (splice variants), 192 orthologues, 20 paralogues and is associated with 6 phenotypes. Biased expression in Lung (RPKM 75.8), Kidney (RPKM 67.7) and 7 other tissues.

Summary

Enables 3',5'-cyclic-GMP phosphodiesterase activity. Involved in cGMP-mediated signaling. Located in perikaryon. Orthologous to human PDE9A (phosphodiesterase 9A). [provided by Alliance of Genome Resources, Apr 2022]

Pde9a Products (1)

mRNA Protein Name
NM_138543.1 NP_612552.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in negative regulation of neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
31821840 RGD
involved in positive regulation of long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
31578258 RGD
Cellular Component GO Annotation Evidence References Source
located in perikaryon IDA
IDA: Inferred from direct assay
19445908 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pde9a Protein Structure

PDEase_I

PDEase_I: pfam00233 (249 - 477)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 534 a.a.
Protein Preferred Names Protein Names

high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-15441 Edelinontrine Inhibitor 99.85% Phase 2
HY-112831 Osoresnontrine Inhibitor 99.94% Phase 2

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-104028 BAY 73-6691 Inhibitor 99.38% Unkown
HY-12788 PF-04449613 Inhibitor 99.83% Unkown
HY-126137 PDE9-IN-1 Inhibitor 99.70% Unkown
HY-152106 BAY-7081 Inhibitor 99.03% Unkown
HY-104028B (S)-BAY 73-6691 Control 99.71% Unkown
HY-12788A (S)-PF-04449613 Inhibitor 99.85% Unkown
HY-152106A (+)-BAY-7081 Inhibitor 99.21% Unkown
HY-152106B (±)-BAY-7081 Inhibitor 99.06% Unkown
HY-RS10246 PDE9A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10247 Pde9a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10248 Pde9a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde9a NCBI NCBI:5152