C1s - complement C1s Gene

Also Known as r-gsp

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 192262

Summary

Predicted to enable identical protein binding activity and serine-type endopeptidase activity. Involved in glial cell differentiation and response to cAMP. Located in extracellular region. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome periodontal type 2. Orthologous to human C1S (complement C1s). [provided by Alliance of Genome Resources, Apr 2022]

C1s Products (1)

mRNA Protein Name
NM_138900.2 NP_620255.2 complement C1s subcomponent precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in glial cell differentiation IEP
IEP: Inferred from expression pattern
9524231 RGD
involved in response to cAMP IEP
IEP: Inferred from expression pattern
12393260 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
12393260 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

complement C1s subcomponent

  • C1 esterase

  • complement component 1 subcomponent s

  • complement component 1, s subcomponent

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99050 Sutimlimab Inhibitor 98.81% Unkown

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990091 Riliprubart Inhibitor 99.90% Phase 3

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-50875 BCX 1470 methanesulfonate Inhibitor 99.87% Unkown
HY-W371165 C1s-IN-1 trihydrochloride Inhibitor 99.73% Unkown
HY-P10827 PIC1 PA Inhibitor 98.37% Unkown
HY-149278 Complement C1s-IN-1 Inhibitor 97.77% Unkown
HY-158469 Disialylated Core 1 O-glycan (C1S(3,6)2), 2-AB labelled 98.91% Unkown
HY-15191B (S)-Sabutoclax Inhibitor 98.03% Unkown
HY-50874 BCX 1470 Inhibitor / Unkown
HY-158468 Sialylated Core 1 O-glycan (C1S(3)1), 2AB labelled / Unkown
HY-158472 Sialylated Core 1 O-glycan (C1S(3)1) / Unkown
HY-E70390 C1s Enzyme Antagonist / Unkown
HY-E70534 C1s Proenzyme / Unkown
HY-N0215S16 L-Phenylalanine-13C-1 / Unkown
HY-RS01737 C1S Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W371164 C1s-IN-1 Inhibitor / Unkown
HY-149690 O-Phthalimide-C1-S-C1-acid / Unkown
HY-149691 O-Phthalimide-C1-S-C5-acid / Unkown
HY-RS24256 C1s Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991127 Claseprubart Inhibitor 99% Unkown
HY-P991629 C1 Esterase Inhibitor (Human) Inhibitor 95.00% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens C1s NCBI NCBI:716