1. Immunology/Inflammation
  2. Complement System
  3. BCX 1470 methanesulfonate

BCX 1470 methanesulfonate 

Cat. No.: HY-50875 Purity: 99.43%
Handling Instructions

BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin.

For research use only. We do not sell to patients.

BCX 1470 methanesulfonate Chemical Structure

BCX 1470 methanesulfonate Chemical Structure

CAS No. : 217099-44-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 462 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 660 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Other Forms of BCX 1470 methanesulfonate:

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Description

BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin.

IC50 & Target

IC50: 96 nM (Factor D); 1.6 nM (C1s); 326 nM (Trypsin)

In Vitro

BCX 1470 methanesulfonate is serine protease inhibitor. BCX 1470 methanesulfonate blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro, also blocked development of RPA-induced edema in the rat.

Molecular Weight

398.48

Formula

C₁₅H₁₄N₂O₅S₃

CAS No.

217099-44-0

SMILES

N=C(C1=CC2=CC=C(OC(C3=CC=CS3)=O)C=C2S1)N.O=S(O)(C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 33.33 mg/mL (83.64 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5095 mL 12.5477 mL 25.0954 mL
5 mM 0.5019 mL 2.5095 mL 5.0191 mL
10 mM 0.2510 mL 1.2548 mL 2.5095 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.27 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.27 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.27 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.43%

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

BCX 1470BCX1470BCX-1470Complement SystemesterolyticactivityfactorDC1strypsinInhibitorinhibitorinhibit

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Product name:
BCX 1470 methanesulfonate
Cat. No.:
HY-50875
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