Cdk12 - cyclin-dependent kinase 12 Gene

Also Known as Hgn; Crk7; Pksc; Crkrs

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 192350

About Cdk12

Primary_assembly 10: 83,201,211-83,280,888 forward strand.mRatBN7.2:CM026983.1

This gene has 4 transcripts (splice variants), 206 orthologues, 24 paralogues and is associated with 6 phenotypes. Biased expression in Thymus (RPKM 211.9), Spleen (RPKM 175.4) and 9 other tissues.

Summary

Enables cyclin binding activity. Involved in RNA splicing and regulation of RNA splicing. Located in nuclear speck. Part of nuclear cyclin-dependent protein kinase holoenzyme complex. Orthologous to human CDK12 (cyclin dependent kinase 12). [provided by Alliance of Genome Resources, Apr 2022]

Cdk12 Products (2)

mRNA Protein Name
NM_138916.2 NP_620271.1 cyclin-dependent kinase 12 isoform 2
NM_001033867.2 NP_001029039.1 cyclin-dependent kinase 12 isoform 1

Cdk12 Protein Structure

STKc_CDK12

STKc_CDK12: cd07864 (714 - 1015)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1484 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 12

  • CDC2-related kinase 7

  • CDC2-related protein kinase 7

  • Cdc2-related kinase, arginine/serine-rich

  • cell division cycle 2-related protein kinase 7

  • cell division protein kinase 12

  • hippyragranin

  • protein kinase for splicing component

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-138293 SY-5609 Inhibitor 99.93% Phase 1

Pre-clinical Phase

Bioactive Molecules (49)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-80013 THZ1 Inhibitor 99.84% Unkown
HY-103618 THZ531 Inhibitor 99.86% Unkown
HY-130250 SR-4835 Inhibitor 99.73% Unkown
HY-139039 BSJ-4-116 Inhibitor 99.87% Unkown
HY-80013A THZ1 Hydrochloride Inhibitor 99.06% Unkown
HY-168555 YJ1206 Degrader 97.26% Unkown
HY-112626 CDK12-IN-2 Inhibitor 99.36% Unkown
HY-153244 MFH290 Inhibitor 98.29% Unkown
HY-112261 CDK12-IN-3 Inhibitor 99.86% Unkown
HY-151110A PROTAC CDK12/13 Degrader-1 TFA Degrader 99.12% Unkown
HY-163944 LL-K12-18 Inhibitor 98.42% Unkown
HY-162706 BSJ-5-63 Degrader 99.97% Unkown
HY-168162 ZLC491 Degrader 98.51% Unkown
HY-145072 BSJ-01-175 Inhibitor 99.88% Unkown
HY-139329 CDK12-IN-6 Inhibitor 99.15% Unkown
HY-139980 CDK9-IN-13 Inhibitor 99.94% Unkown
HY-171787A PPA-037 TFA Inhibitor 99.42% Unkown
HY-151110 PROTAC CDK12/13 Degrader-1 Degrader 98.01% Unkown
HY-117203A CDK12-IN-E9 Inhibitor 99.71% Unkown
HY-155787 SHR5428 Inhibitor 99.80% Unkown
HY-139328 CDK12-IN-5 Inhibitor 98.03% Unkown
HY-144691 PP-C8 Inhibitor 99.99% Unkown
HY-172970 HQY1428 Inhibitor 99.65% Unkown
HY-173059 CDK12/13-IN-3 Inhibitor 99.14% Unkown
HY-168556 YJ9069 Degrader / Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-171787 PPA-037 Inhibitor / Unkown
HY-171786 CDK12-IN-8 Inhibitor 99.52% Unkown
HY-181035 DN1679 Degrader / Unkown
HY-150948 CDK12 ligand-2 Ligand / Unkown
HY-180355 SY-5102 Inhibitor / Unkown
HY-168163 CDK12/13 ligand 1 Degrader / Unkown
HY-168658 CDK12/13 ligand 2 Degrader / Unkown
HY-181645 CDK12-IN-9 Inhibitor / Unkown
HY-181036 CDK12/13 ligand 3 Ligand / Unkown
HY-180912 HS-36 Inhibitor / Unkown
HY-173147 CDK2-IN-42 Inhibitor / Unkown
HY-150641 CDK-IN-9 Inhibitor / Unkown
HY-181405 SR-5037 Inhibitor 99.58% Unkown
HY-151878 CDK7-IN-20 Inhibitor / Unkown
HY-176279 Hsp90-IN-42 Inhibitor / Unkown
HY-173042 CDK12/13-IN-2 Inhibitor / Unkown
HY-48507 CDK12/13 ligand 4 Ligand / Unkown
HY-139327 CDK12-IN-4 Inhibitor / Unkown
HY-173273 YJZ5118 Inhibitor / Unkown
HY-162528 CDK12-IN-7 Inhibitor / Unkown
HY-114567 GW780056X Inhibitor / Unkown
HY-172224 PARP1/CDK12-IN-1 Inhibitor / Unkown
HY-176790 CDK12-Cyclin K ligand-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk12 NCBI NCBI:51755