2. Gene
  3. Cdk12 - cyclin-dependent kinase 12 Gene

Cdk12 - cyclin-dependent kinase 12 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Hgn; Crk7; Pksc; Crkrs

Gene ID: 192350 | Gene type: protein coding

About Cdk12

Primary_assembly 10: 83,201,211-83,280,888 forward strand.mRatBN7.2:CM026983.1

This gene has 4 transcripts (splice variants), 206 orthologues, 24 paralogues and is associated with 6 phenotypes. Biased expression in Thymus (RPKM 211.9), Spleen (RPKM 175.4) and 9 other tissues.

Summary

Enables cyclin binding activity. Involved in RNA splicing and regulation of RNA splicing. Located in nuclear speck. Part of nuclear cyclin-dependent protein kinase holoenzyme complex. Orthologous to human CDK12 (cyclin dependent kinase 12). [provided by Alliance of Genome Resources, Apr 2022]

Cdk12 Products(2)

mRNA Protein Name
NM_138916.2 NP_620271.1 cyclin-dependent kinase 12 isoform 2
NM_001033867.2 NP_001029039.1 cyclin-dependent kinase 12 isoform 1

Cdk12 Protein Structure

STKc_CDK12

STKc_CDK12: cd07864 (714 - 1015)

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  • 1484 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 12

CDC2-related kinase 7

CDC2-related protein kinase 7

Cdc2-related kinase, arginine/serine-rich

cell division cycle 2-related protein kinase 7

cell division protein kinase 12

hippyragranin

protein kinase for splicing component

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-138293 SY-5609 Inhibitor 99.66% Phase 1
Pre-clinical Phase
Bioactive Molecules (19)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-80013 THZ1 Inhibitor 99.84% Unkown
HY-103618 THZ531 Inhibitor 99.86% Unkown
HY-130250 SR-4835 Inhibitor 99.73% Unkown
HY-139039 BSJ-4-116 Inhibitor 98.73% Unkown
HY-112261 CDK12-IN-3 Inhibitor 99.57% Unkown
HY-80013A THZ1 Hydrochloride Inhibitor 98.78% Unkown
HY-112626 CDK12-IN-2 Inhibitor 99.44% Unkown
HY-117203A CDK12-IN-E9 Inhibitor 99.97% Unkown
HY-151110A PROTAC CDK12/13 Degrader-1 TFA Degrader 98.37% Unkown
HY-145072 BSJ-01-175 Inhibitor 99.45% Unkown
HY-139328 CDK12-IN-5 Inhibitor 99.01% Unkown
HY-139980 CDK9-IN-13 Inhibitor 99.22% Unkown
HY-151110 PROTAC CDK12/13 Degrader-1 Degrader / Unkown
HY-139329 CDK12-IN-6 Inhibitor / Unkown
HY-150641 CDK-IN-9 Inhibitor / Unkown
HY-151878 CDK7-IN-20 Inhibitor / Unkown
HY-155787 SHR5428 Inhibitor / Unkown
HY-139327 CDK12-IN-4 Inhibitor / Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk12 NCBI NCBI:51755