2. Cell Cycle/DNA Damage
  3. CDK
  4. PPA-037 TFA

PPA-037 TFA is an orally active, highly potent and selective inhibitor of cyclin-dependent kinase 12 (CDK12). PPA-037 TFA induces the degradation of cyclin K (Cyclin K), enhancing antiproliferative effects on tumor cells. PPA-037 TFA is promising for research of cancers.

For research use only. We do not sell to patients.

PPA-037 TFA

PPA-037 TFA Chemical Structure

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of PPA-037 TFA:

PPA-037 TFA Related Antibodies

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  • Biological Activity

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Description

PPA-037 TFA is an orally active, highly potent and selective inhibitor of cyclin-dependent kinase 12 (CDK12). PPA-037 TFA induces the degradation of cyclin K (Cyclin K), enhancing antiproliferative effects on tumor cells. PPA-037 TFA is promising for research of cancers[1].

IC50 & Target

CDK12/Cyclin K

 

Molecular Weight

539.55

Formula

C27H28F3N7O2
Appearance

Solid

Color

Light yellow to yellow

SMILES

OC(C(F)(F)F)=O.C1(CNC2=CC(N[C@H]3CCNC3)=NC4=C(C5CC5)C=NN24)=CC=C(C6=CC=CC=N6)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (185.34 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8534 mL 9.2670 mL 18.5340 mL
5 mM 0.3707 mL 1.8534 mL 3.7068 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.8534 mL 9.2670 mL 18.5340 mL 46.3349 mL
5 mM 0.3707 mL 1.8534 mL 3.7068 mL 9.2670 mL
10 mM 0.1853 mL 0.9267 mL 1.8534 mL 4.6335 mL
15 mM 0.1236 mL 0.6178 mL 1.2356 mL 3.0890 mL
20 mM 0.0927 mL 0.4633 mL 0.9267 mL 2.3167 mL
25 mM 0.0741 mL 0.3707 mL 0.7414 mL 1.8534 mL
30 mM 0.0618 mL 0.3089 mL 0.6178 mL 1.5445 mL
40 mM 0.0463 mL 0.2317 mL 0.4633 mL 1.1584 mL
50 mM 0.0371 mL 0.1853 mL 0.3707 mL 0.9267 mL
60 mM 0.0309 mL 0.1544 mL 0.3089 mL 0.7722 mL
80 mM 0.0232 mL 0.1158 mL 0.2317 mL 0.5792 mL
100 mM 0.0185 mL 0.0927 mL 0.1853 mL 0.4633 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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PPA-037 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PPA-037PPA037PPA 037CDKCyclin dependent kinaseorally activeCDK12Cyclin KantiproliferativeInhibitorinhibitorinhibit

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