2. Gene
  3. CDK12 - cyclin dependent kinase 12 Gene

CDK12 - cyclin dependent kinase 12 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CRK7; CRKR; CRKRS

Gene ID: 51755 | Gene type: protein coding

About CDK12

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:39,461,486-39,567,559 (from NCBI)

This gene has 10 transcripts (splice variants), 206 orthologues, 26 paralogues and is associated with 104 phenotypes. Ubiquitous expression in testis (RPKM 8.6), bone marrow (RPKM 8.1) and 25 other tissues.

Summary

Enables RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin binding activity. Involved in phosphorylation of RNA polymerase II C-terminal domain; protein autophosphorylation; and regulation of MAP kinase activity. Located in nuclear speck. Part of cyclin K-CDK12 complex. [provided by Alliance of Genome Resources, Apr 2022]

CDK12 Products(50)

mRNA Protein Name
XM_047436286.1 XP_047292242.1 cyclin-dependent kinase 12 isoform X6
XM_047436262.1 XP_047292218.1 cyclin-dependent kinase 12 isoform X4
XM_047436267.1 XP_047292223.1 cyclin-dependent kinase 12 isoform X5
XM_047436289.1 XP_047292245.1 cyclin-dependent kinase 12 isoform X7
XM_047436258.1 XP_047292214.1 cyclin-dependent kinase 12 isoform X3
XM_047436274.1 XP_047292230.1 cyclin-dependent kinase 12 isoform X5
XM_011524907.3 XP_011523209.1 cyclin-dependent kinase 12 isoform X7
XM_047436276.1 XP_047292232.1 cyclin-dependent kinase 12 isoform X5
XM_047436292.1 XP_047292248.1 cyclin-dependent kinase 12 isoform X8
XM_047436277.1 XP_047292233.1 cyclin-dependent kinase 12 isoform X5
XM_047436272.1 XP_047292228.1 cyclin-dependent kinase 12 isoform X5
XM_047436265.1 XP_047292221.1 cyclin-dependent kinase 12 isoform X5
XM_047436288.1 XP_047292244.1 cyclin-dependent kinase 12 isoform X7
XM_011524895.3 XP_011523197.1 cyclin-dependent kinase 12 isoform X3
XM_047436284.1 XP_047292240.1 cyclin-dependent kinase 12 isoform X6
XM_047436287.1 XP_047292243.1 cyclin-dependent kinase 12 isoform X7
XM_047436268.1 XP_047292224.1 cyclin-dependent kinase 12 isoform X5
XM_047436280.1 XP_047292236.1 cyclin-dependent kinase 12 isoform X6
XM_047436261.1 XP_047292217.1 cyclin-dependent kinase 12 isoform X3
XM_047436259.1 XP_047292215.1 cyclin-dependent kinase 12 isoform X3
XM_011524897.3 XP_011523199.1 cyclin-dependent kinase 12 isoform X3
NM_016507.4 NP_057591.2 cyclin-dependent kinase 12 isoform 1
XM_017024753.3 XP_016880242.1 cyclin-dependent kinase 12 isoform X8
XM_047436281.1 XP_047292237.1 cyclin-dependent kinase 12 isoform X6
XM_047436256.1 XP_047292212.1 cyclin-dependent kinase 12 isoform X3
XM_047436255.1 XP_047292211.1 cyclin-dependent kinase 12 isoform X3
XM_047436273.1 XP_047292229.1 cyclin-dependent kinase 12 isoform X5
XM_047436290.1 XP_047292246.1 cyclin-dependent kinase 12 isoform X8
XM_047436264.1 XP_047292220.1 cyclin-dependent kinase 12 isoform X4
XM_047436283.1 XP_047292239.1 cyclin-dependent kinase 12 isoform X6
XM_047436275.1 XP_047292231.1 cyclin-dependent kinase 12 isoform X5
XM_011524906.3 XP_011523208.1 cyclin-dependent kinase 12 isoform X3
XM_047436279.1 XP_047292235.1 cyclin-dependent kinase 12 isoform X5
NM_015083.4 NP_055898.1 cyclin-dependent kinase 12 isoform 2
XM_047436278.1 XP_047292234.1 cyclin-dependent kinase 12 isoform X5
XM_047436282.1 XP_047292238.1 cyclin-dependent kinase 12 isoform X6
XM_047436293.1 XP_047292249.1 cyclin-dependent kinase 12 isoform X9
XM_011524894.3 XP_011523196.1 cyclin-dependent kinase 12 isoform X3
XM_047436260.1 XP_047292216.1 cyclin-dependent kinase 12 isoform X3
XM_011524893.3 XP_011523195.1 cyclin-dependent kinase 12 isoform X3
XM_011524898.3 XP_011523200.1 cyclin-dependent kinase 12 isoform X3
XM_005257456.5 XP_005257513.1 cyclin-dependent kinase 12 isoform X1
XM_047436257.1 XP_047292213.1 cyclin-dependent kinase 12 isoform X3
XM_047436291.1 XP_047292247.1 cyclin-dependent kinase 12 isoform X8
XM_047436270.1 XP_047292226.1 cyclin-dependent kinase 12 isoform X5
XM_047436253.1 XP_047292209.1 cyclin-dependent kinase 12 isoform X2
XM_047436285.1 XP_047292241.1 cyclin-dependent kinase 12 isoform X6
XM_047436269.1 XP_047292225.1 cyclin-dependent kinase 12 isoform X5
XM_047436266.1 XP_047292222.1 cyclin-dependent kinase 12 isoform X5
XM_047436263.1 XP_047292219.1 cyclin-dependent kinase 12 isoform X4

CDK12 Protein Structure

Pkinase

Pkinase: Protein kinase domain (728 - 1020)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1490 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 12

CDC2-related protein kinase 7

Cdc2-related kinase, arginine/serine-rich

cell division cycle 2-related protein kinase 7

cell division protein kinase 12

Related Diseases

Diseases Alias
Adenosquamous Prostate Carcinoma

Adenosquamous Carcinoma Of Prostate

Adenosquamous Carcinoma Of The Prostate
Brachydactyly, Type E1

Brachydactyly Type E1

Brachydactyly Type E

BDE1

Brachydactyly, Type E

Bde

Type E Brachydactyly

Brachydactyly E1

Brachydactyly Syndrome Type E
Gastric Cancer

Stomach Cancer

Stomach Carcinoma

Gastric Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Lung Cancer Susceptibility 3

Lung Adenocarcinoma

Adenocarcinoma Of Lung

LNCR3

Adenocarcinoma Of Lung, Susceptibility To

Bronchogenic Lung Adenocarcinoma

Nonsmall Cell Adenocarcinoma

Adenocarcinoma Lung

Lung Adenocarcinomas

Non-Small Cell Adenocarcinoma
Congenital Heart Defects, Dysmorphic Facial Features, And Intellectual Developmental Disorder

CHDFIDD

Cdk13-Related Chdfidd

Cdk13-Related Disorder

Cdk13-Related Congenital Heart Defects, Dysmorphic Facial Features, Intellectual Developmental Disorder
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome

Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer

Breast And/Or Ovarian Cancer

Breast And Ovarian Cancer Syndrome

Hboc Syndrome

Hereditary Breast And Ovarian Cancer

Brca1- Brca2-Associated Hboc
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-138293 SY-5609 Inhibitor 99.66% Phase 1
Pre-clinical Phase
Bioactive Molecules (19)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-80013 THZ1 Inhibitor 99.84% Unkown
HY-103618 THZ531 Inhibitor 99.86% Unkown
HY-130250 SR-4835 Inhibitor 99.73% Unkown
HY-139039 BSJ-4-116 Inhibitor 98.73% Unkown
HY-112261 CDK12-IN-3 Inhibitor 99.57% Unkown
HY-80013A THZ1 Hydrochloride Inhibitor 98.78% Unkown
HY-112626 CDK12-IN-2 Inhibitor 99.44% Unkown
HY-117203A CDK12-IN-E9 Inhibitor 99.97% Unkown
HY-151110A PROTAC CDK12/13 Degrader-1 TFA Degrader 98.37% Unkown
HY-145072 BSJ-01-175 Inhibitor 99.45% Unkown
HY-139328 CDK12-IN-5 Inhibitor 99.01% Unkown
HY-139980 CDK9-IN-13 Inhibitor 99.22% Unkown
HY-151110 PROTAC CDK12/13 Degrader-1 Degrader / Unkown
HY-139329 CDK12-IN-6 Inhibitor / Unkown
HY-150641 CDK-IN-9 Inhibitor / Unkown
HY-151878 CDK7-IN-20 Inhibitor / Unkown
HY-155787 SHR5428 Inhibitor / Unkown
HY-139327 CDK12-IN-4 Inhibitor / Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CDK12 VGNC VGNC:39044
Bos taurus CDK12 VGNC VGNC:27117
Mus musculus CDK12 MGD MGI:1098802
Macaca mulatta CDK12 VGNC VGNC:71083
Rattus norvegicus CDK12 RGD RGD:621111
Felis catus CDK12 VGNC VGNC:60694
Others CDK12 NCBI