CDK12 - cyclin dependent kinase 12 Gene

Also Known as CRK7; CRKR; CRKRS

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51755

About CDK12

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:39,461,486-39,567,559 (from NCBI)

This gene has 10 transcripts (splice variants), 206 orthologues, 26 paralogues and is associated with 104 phenotypes. Ubiquitous expression in testis (RPKM 8.6), bone marrow (RPKM 8.1) and 25 other tissues.

Summary

Enables RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin binding activity. Involved in phosphorylation of RNA polymerase II C-terminal domain; protein autophosphorylation; and regulation of MAP kinase activity. Located in nuclear speck. Part of cyclin K-CDK12 complex. [provided by Alliance of Genome Resources, Apr 2022]

CDK12 Products (50)

mRNA Protein Name
XM_047436286.1 XP_047292242.1 cyclin-dependent kinase 12 isoform X6
XM_047436262.1 XP_047292218.1 cyclin-dependent kinase 12 isoform X4
XM_047436267.1 XP_047292223.1 cyclin-dependent kinase 12 isoform X5
XM_047436289.1 XP_047292245.1 cyclin-dependent kinase 12 isoform X7
XM_047436258.1 XP_047292214.1 cyclin-dependent kinase 12 isoform X3
XM_047436274.1 XP_047292230.1 cyclin-dependent kinase 12 isoform X5
XM_011524907.3 XP_011523209.1 cyclin-dependent kinase 12 isoform X7
XM_047436276.1 XP_047292232.1 cyclin-dependent kinase 12 isoform X5
XM_047436292.1 XP_047292248.1 cyclin-dependent kinase 12 isoform X8
XM_047436277.1 XP_047292233.1 cyclin-dependent kinase 12 isoform X5
XM_047436272.1 XP_047292228.1 cyclin-dependent kinase 12 isoform X5
XM_047436265.1 XP_047292221.1 cyclin-dependent kinase 12 isoform X5
XM_047436288.1 XP_047292244.1 cyclin-dependent kinase 12 isoform X7
XM_011524895.3 XP_011523197.1 cyclin-dependent kinase 12 isoform X3
XM_047436284.1 XP_047292240.1 cyclin-dependent kinase 12 isoform X6
XM_047436287.1 XP_047292243.1 cyclin-dependent kinase 12 isoform X7
XM_047436268.1 XP_047292224.1 cyclin-dependent kinase 12 isoform X5
XM_047436280.1 XP_047292236.1 cyclin-dependent kinase 12 isoform X6
XM_047436261.1 XP_047292217.1 cyclin-dependent kinase 12 isoform X3
XM_047436259.1 XP_047292215.1 cyclin-dependent kinase 12 isoform X3
XM_011524897.3 XP_011523199.1 cyclin-dependent kinase 12 isoform X3
NM_016507.4 NP_057591.2 cyclin-dependent kinase 12 isoform 1
XM_017024753.3 XP_016880242.1 cyclin-dependent kinase 12 isoform X8
XM_047436281.1 XP_047292237.1 cyclin-dependent kinase 12 isoform X6
XM_047436256.1 XP_047292212.1 cyclin-dependent kinase 12 isoform X3
XM_047436255.1 XP_047292211.1 cyclin-dependent kinase 12 isoform X3
XM_047436273.1 XP_047292229.1 cyclin-dependent kinase 12 isoform X5
XM_047436290.1 XP_047292246.1 cyclin-dependent kinase 12 isoform X8
XM_047436264.1 XP_047292220.1 cyclin-dependent kinase 12 isoform X4
XM_047436283.1 XP_047292239.1 cyclin-dependent kinase 12 isoform X6
XM_047436275.1 XP_047292231.1 cyclin-dependent kinase 12 isoform X5
XM_011524906.3 XP_011523208.1 cyclin-dependent kinase 12 isoform X3
XM_047436279.1 XP_047292235.1 cyclin-dependent kinase 12 isoform X5
NM_015083.4 NP_055898.1 cyclin-dependent kinase 12 isoform 2
XM_047436278.1 XP_047292234.1 cyclin-dependent kinase 12 isoform X5
XM_047436282.1 XP_047292238.1 cyclin-dependent kinase 12 isoform X6
XM_047436293.1 XP_047292249.1 cyclin-dependent kinase 12 isoform X9
XM_011524894.3 XP_011523196.1 cyclin-dependent kinase 12 isoform X3
XM_047436260.1 XP_047292216.1 cyclin-dependent kinase 12 isoform X3
XM_011524893.3 XP_011523195.1 cyclin-dependent kinase 12 isoform X3
XM_011524898.3 XP_011523200.1 cyclin-dependent kinase 12 isoform X3
XM_005257456.5 XP_005257513.1 cyclin-dependent kinase 12 isoform X1
XM_047436257.1 XP_047292213.1 cyclin-dependent kinase 12 isoform X3
XM_047436291.1 XP_047292247.1 cyclin-dependent kinase 12 isoform X8
XM_047436270.1 XP_047292226.1 cyclin-dependent kinase 12 isoform X5
XM_047436253.1 XP_047292209.1 cyclin-dependent kinase 12 isoform X2
XM_047436285.1 XP_047292241.1 cyclin-dependent kinase 12 isoform X6
XM_047436269.1 XP_047292225.1 cyclin-dependent kinase 12 isoform X5
XM_047436266.1 XP_047292222.1 cyclin-dependent kinase 12 isoform X5
XM_047436263.1 XP_047292219.1 cyclin-dependent kinase 12 isoform X4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II CTD heptapeptide repeat kinase activity IDA
IDA: Inferred from direct assay
22988298 GOA
enables RNA polymerase II CTD heptapeptide repeat kinase activity IMP
IMP: Inferred from mutant phenotype
20952539 GOA
enables cyclin binding IPI
IPI: Inferred from physical interaction
22012619 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12841360 GOA
enables protein kinase activity IDA
IDA: Inferred from direct assay
11683387 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20952539 GOA
involved in positive regulation of transcription elongation by RNA polymerase II IDA
IDA: Inferred from direct assay
22988298 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
11683387 GOA
involved in regulation of MAP kinase activity IMP
IMP: Inferred from mutant phenotype
19651820 GOA
involved in transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
22988298 GOA
Cellular Component GO Annotation Evidence References Source
part of cyclin K-CDK12 complex IPI
IPI: Inferred from physical interaction
22012619 GOA
located in nuclear speck IDA
IDA: Inferred from direct assay
11683387 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK12 Protein Structure

Pkinase

Pkinase: Protein kinase domain (728 - 1020)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1490 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 12

  • CDC2-related protein kinase 7

  • Cdc2-related kinase, arginine/serine-rich

  • cell division cycle 2-related protein kinase 7

  • cell division protein kinase 12

Related Diseases

Diseases Alias
Adenosquamous Prostate Carcinoma

  • Adenosquamous Carcinoma Of Prostate

  • Adenosquamous Carcinoma Of The Prostate
Brachydactyly, Type E1

  • Brachydactyly Type E1

  • Brachydactyly Type E

  • BDE1

  • Brachydactyly, Type E

  • Bde

  • Type E Brachydactyly

  • Brachydactyly E1

  • Brachydactyly Syndrome Type E
Gastric Cancer

  • Stomach Cancer

  • Stomach Carcinoma

  • Gastric Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Lung Cancer Susceptibility 3

  • Lung Adenocarcinoma

  • Adenocarcinoma Of Lung

  • LNCR3

  • Adenocarcinoma Of Lung, Susceptibility To

  • Bronchogenic Lung Adenocarcinoma

  • Nonsmall Cell Adenocarcinoma

  • Adenocarcinoma Lung

  • Lung Adenocarcinomas

  • Non-Small Cell Adenocarcinoma
Congenital Heart Defects, Dysmorphic Facial Features, And Intellectual Developmental Disorder

  • CHDFIDD

  • Cdk13-Related Chdfidd

  • Cdk13-Related Disorder

  • Cdk13-Related Congenital Heart Defects, Dysmorphic Facial Features, Intellectual Developmental Disorder
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Protection Against

  • Lung Cancer, Susceptibility To

  • Adenocarcinoma Of Lung, Somatic

  • Nonsmall Cell Lung Cancer

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Fanconi Anemia, Complementation Group A

  • Fanconi Anemia

  • Fanconi Pancytopenia

  • Fanconi Anemia Complementation Group A

  • FANCA

  • Fa

  • Fanconi Panmyelopathy

  • Fanconi'S Anemia

  • Fanconi Anaemia

  • Fanconi'S Anaemia

  • Fanconi Hypoplastic Anemia

  • Estren-Dameshek Variant Of Fanconi Anemia

  • Estren-Dameshek Variant Of Fanconi Pancytopenia

  • Fanconi Anemia Estren-Dameshek Variant

  • Fanconis Anemia
Hereditary Breast Ovarian Cancer Syndrome

  • Hereditary Breast And Ovarian Cancer Syndrome

  • Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer

  • Breast And/Or Ovarian Cancer

  • Breast And Ovarian Cancer Syndrome

  • Hboc Syndrome

  • Hereditary Breast And Ovarian Cancer

  • Brca1- Brca2-Associated Hboc
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-138293 SY-5609 Inhibitor 99.93% Phase 1

Pre-clinical Phase

Bioactive Molecules (48)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-80013 THZ1 Inhibitor 99.84% Unkown
HY-103618 THZ531 Inhibitor 99.86% Unkown
HY-130250 SR-4835 Inhibitor 99.73% Unkown
HY-139039 BSJ-4-116 Inhibitor 99.87% Unkown
HY-80013A THZ1 Hydrochloride Inhibitor 99.06% Unkown
HY-168555 YJ1206 Degrader 97.26% Unkown
HY-112626 CDK12-IN-2 Inhibitor 99.36% Unkown
HY-153244 MFH290 Inhibitor 98.29% Unkown
HY-151110A PROTAC CDK12/13 Degrader-1 TFA Degrader 99.12% Unkown
HY-112261 CDK12-IN-3 Inhibitor 99.86% Unkown
HY-163944 LL-K12-18 Inhibitor 98.42% Unkown
HY-162706 BSJ-5-63 Degrader 99.97% Unkown
HY-168162 ZLC491 Degrader 98.51% Unkown
HY-145072 BSJ-01-175 Inhibitor 99.88% Unkown
HY-139329 CDK12-IN-6 Inhibitor 99.15% Unkown
HY-139980 CDK9-IN-13 Inhibitor 99.94% Unkown
HY-171787A PPA-037 TFA Inhibitor 99.42% Unkown
HY-151110 PROTAC CDK12/13 Degrader-1 Degrader 98.01% Unkown
HY-117203A CDK12-IN-E9 Inhibitor 99.71% Unkown
HY-155787 SHR5428 Inhibitor 99.80% Unkown
HY-139328 CDK12-IN-5 Inhibitor 98.03% Unkown
HY-144691 PP-C8 Inhibitor 99.99% Unkown
HY-172970 HQY1428 Inhibitor 99.65% Unkown
HY-168556 YJ9069 Degrader / Unkown
HY-173059 CDK12/13-IN-3 Inhibitor 99.14% Unkown
HY-171786 CDK12-IN-8 Inhibitor 99.52% Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-171787 PPA-037 Inhibitor / Unkown
HY-181035 DN1679 Degrader / Unkown
HY-150641 CDK-IN-9 Inhibitor / Unkown
HY-181405 SR-5037 Inhibitor 99.58% Unkown
HY-176279 Hsp90-IN-42 Inhibitor / Unkown
HY-168658 CDK12/13 ligand 2 Degrader / Unkown
HY-48507 CDK12/13 ligand 4 Ligand / Unkown
HY-139327 CDK12-IN-4 Inhibitor / Unkown
HY-173273 YJZ5118 Inhibitor / Unkown
HY-162528 CDK12-IN-7 Inhibitor / Unkown
HY-114567 GW780056X Inhibitor / Unkown
HY-150948 CDK12 ligand-2 Ligand / Unkown
HY-151878 CDK7-IN-20 Inhibitor / Unkown
HY-168163 CDK12/13 ligand 1 Degrader / Unkown
HY-173042 CDK12/13-IN-2 Inhibitor / Unkown
HY-181645 CDK12-IN-9 Inhibitor / Unkown
HY-181036 CDK12/13 ligand 3 Ligand / Unkown
HY-180912 HS-36 Inhibitor / Unkown
HY-173147 CDK2-IN-42 Inhibitor / Unkown
HY-172224 PARP1/CDK12-IN-1 Inhibitor / Unkown
HY-176790 CDK12-Cyclin K ligand-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CDK12 VGNC VGNC:39044
Bos taurus CDK12 VGNC VGNC:27117
Mus musculus CDK12 MGD MGI:1098802
Macaca mulatta CDK12 VGNC VGNC:71083
Rattus norvegicus CDK12 RGD RGD:621111
Felis catus CDK12 VGNC VGNC:60694
Others CDK12 NCBI