country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-190277

Copy Link Print Information

H-APPAMP-023

H-APPAMP-023 is a molecular glue. H-APPAMP-023 inhibits CDK activity, with IC₅₀ values of 102 nM and 702 nM for CDK7 and CDK12, respectively.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2654076-02-3
Formule: C₂₄H₂₉F₃N₈O
Masse moléculaire:502.54

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

H-APPAMP-023 Chemical Structure

CAS No.: 2654076-02-3

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

H-APPAMP-023 is a molecular glue. H-APPAMP-023 inhibits CDK activity, with IC₅₀ values of 102 nM and 702 nM for CDK7 and CDK12, respectively^[1].

IC₅₀ & Target

^[1]

CDK7

102 nM (IC₅₀)

CDK12

702 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform CDK :

In Vitro

Cell Cycle Regulation

H-APPAMP-023 inhibits the enzymatic activity of CDK7 in a cell-free system with an IC₅₀ of 102 nM, and shows weak inhibitory activity against CDK12 with an IC₅₀ of 702 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2654076-02-3
Masse moléculaire 502.54
Formule C₂₄H₂₉F₃N₈O
SMILES

CC(C1=C2N=C(NC[C@H]3CCNC[C@@H]3O)C=C(NCC4=C(C(F)(F)F)N5C=CC=CC5=N4)N2N=C1)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Ainscow E, et al; Carrick Therapeutics Limited. Cyclin K degraders. WO 2021/122745 A1. Published 2021 Jun 24.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis

Amount: USD 0.00

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

H-APPAMP-023

Voir tous les produits spécifiques à Isoform CDK

Activité biologique

Description

IC50 & Target

In Vitro

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

H-APPAMP-023 Related Classifications

HY-190277 Related Classifications

Bioz

Keywords

Your Recently Viewed Products

IC₅₀ & Target