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Cat. No.: HY-190279

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H-APPAMP-003

H-APPAMP-003 is a CDK12 inhibitor with an IC₅₀ of 50.2 nM. H-APPAMP-003 shows weak inhibition of CDK7 with an IC₅₀ of 411 nM. H-APPAMP-003 is also a molecular glue.

For research use only. We do not sell to patients.

CAS No.: 2654075-81-5
Formula: C₂₃H₃₀N₈O
Molecular Weight:434.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

H-APPAMP-003 Chemical Structure

CAS No.: 2654075-81-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
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Biological Activity

Description

H-APPAMP-003 is a CDK12 inhibitor with an IC₅₀ of 50.2 nM. H-APPAMP-003 shows weak inhibition of CDK7 with an IC₅₀ of 411 nM. H-APPAMP-003 is also a molecular glue^[1].

IC₅₀ & Target

^[1]

CDK7

411 nM (IC₅₀)

CDK12

50.2 nM (IC₅₀)

All CDK Isoforms :

In Vitro

Cell Cycle Regulation

H-APPAMP-003 inhibits CDK12 activity in a cell-free system with an IC₅₀ of 50.2 nM, and shows weak inhibitory activity against CDK7 with an IC₅₀ of 411 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2654075-81-5
Molecular Weight 434.54
Formula C₂₃H₃₀N₈O
SMILES

CC(C1=C2N=C(NC[C@H]3CCNC[C@@H]3O)C=C(NCC4=CN5C=CC=CC5=N4)N2N=C1)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ainscow E, et al; Carrick Therapeutics Limited. Cyclin K degraders. WO 2021/122745 A1. Published 2021 Jun 24.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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H-APPAMP-003

All CDK Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

H-APPAMP-003 Related Classifications

HY-190279 Related Classifications

Bioz

Keywords

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IC₅₀ & Target