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Art. -Nr.: HY-190278

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H-APPAMP-010

H-APPAMP-010 is a Cyclin K degrader and CDK12/7 inhibitor with IC₅₀ values of 40 and 238 nM for CDK12/7, respectively. H-APPAMP-010 inhibits cancer cell viability. H-APPAMP-010 can be used for cancer research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₄H₃₂N₈O
Molecular Weight:448.56

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

H-APPAMP-010 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

CDK7

238 nM (IC₅₀)

CDK12

40 nM (IC₅₀)

CDK12/Cyclin K

Alle CDK Isoform-spezifische Produkte anzeigen :

In Vitro

Anti-cancer

H-APPAMP-010 (1 μM, 2 h) inhibits cell viability in A673 cells with IC₅₀ = 4.3 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

Molecular Weight 448.56
Formel C₂₄H₃₂N₈O
SMILES

CC1=CC=CC2=NC=C(CNC3=CC(NC[C@H]4CCNC[C@@H]4O)=NC5=C(C(C)C)C=NN35)N12
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Edward AINSCOW, et al. 4-[[(7-aminopyrazolo[1,5-a]pyrimidin-5-yl)amino]methyl]piperidin-3-ol compounds and their therapeutic use. WO2021122745A1. 2022-06-16.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
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H-APPAMP-010

Alle CDK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

In Vitro

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

H-APPAMP-010 Related Classifications

HY-190278 Related Classifications

Bioz

Keywords

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