CDK12-IN-8
Based on 1 Customer Validation
CDK12-IN-8 (Compound Cpd143) is an orally active and highly selective inhibitor of cyclin-dependent kinase 12 (CDK12). CDK12-IN-8 inhibits CDK12-mediated phosphorylation of the C-terminal domain (CTD) serine 2 of RNA polymerase II, interfering with gene transcription elongation and DNA damage repair pathways. CDK12-IN-8 is promising for research of cancers with high CDK12 expression such as small cell lung cancer and triple-negative breast cancer.
For research use only. We do not sell to patients.
- Purity: 99.52%
- CAS No.: 2928619-86-5
- Formula: C21H20F3N7O2
- Molecular Weight:459.42
-
Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
CDK12 |
Chemical Information
-
CAS No. 2928619-86-5
-
Appearance Solid
-
Molecular Weight 459.42
-
Formula C21H20F3N7O2
-
Color White to off-white
-
SMILES
N#CC1=CC2=NN=C(N2C=C1)[C@@H](CCC3)C[C@@H]3NC4=NC=C(C(F)(F)F)C(OC5COC5)=N4
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 250 mg/mL (544.16 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (271 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1767 mL | 10.8833 mL | 21.7666 mL | 54.4164 mL |
| 5 mM | 0.4353 mL | 2.1767 mL | 4.3533 mL | 10.8833 mL | |
| 10 mM | 0.2177 mL | 1.0883 mL | 2.1767 mL | 5.4416 mL | |
| 15 mM | 0.1451 mL | 0.7256 mL | 1.4511 mL | 3.6278 mL | |
| 20 mM | 0.1088 mL | 0.5442 mL | 1.0883 mL | 2.7208 mL | |
| 25 mM | 0.0871 mL | 0.4353 mL | 0.8707 mL | 2.1767 mL | |
| 30 mM | 0.0726 mL | 0.3628 mL | 0.7256 mL | 1.8139 mL | |
| 40 mM | 0.0544 mL | 0.2721 mL | 0.5442 mL | 1.3604 mL | |
| 50 mM | 0.0435 mL | 0.2177 mL | 0.4353 mL | 1.0883 mL | |
| 60 mM | 0.0363 mL | 0.1814 mL | 0.3628 mL | 0.9069 mL | |
| 80 mM | 0.0272 mL | 0.1360 mL | 0.2721 mL | 0.6802 mL | |
| 100 mM | 0.0218 mL | 0.1088 mL | 0.2177 mL | 0.5442 mL |
Powered by Bioz