Rad50 - RAD50 double strand break repair protein Gene

Also Known as Mrell; Rad50l

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19360

Summary

Predicted to enable DNA binding activity; identical protein binding activity; and protein-macromolecule adaptor activity. Predicted to contribute to 3'-5' exonuclease activity; DNA helicase activity; and single-stranded DNA endodeoxyribonuclease activity. Acts upstream of or within chromosome organization involved in meiotic cell cycle and regulation of mitotic cell cycle. Located in pronucleus. Is expressed in several structures, including aorta; hemolymphoid system gland; liver; lung; and testis. Human ortholog(s) of this gene implicated in transitional cell carcinoma. Orthologous to human RAD50 (RAD50 double strand break repair protein). [provided by Alliance of Genome Resources, Apr 2022]

Rad50 Products (1)

mRNA Protein Name
NM_009012.2 NP_033038.2 DNA repair protein RAD50

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
30017584 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within chromosome organization IMP
IMP: Inferred from mutant phenotype
19001091 MGI
acts upstream of or within chromosome organization involved in meiotic cell cycle IMP
IMP: Inferred from mutant phenotype
19001091 MGI
acts upstream of or within regulation of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
19001091 MGI
Cellular Component GO Annotation Evidence References Source
part of Mre11 complex IDA
IDA: Inferred from direct assay
18854157 MGI
located in nucleus IDA
IDA: Inferred from direct assay
17982445 MGI
located in pronucleus IDA
IDA: Inferred from direct assay
17982445 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA repair protein RAD50

  • RAD50 homolog

  • mRad50

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19959 Mirin 99.63% Unkown
HY-117693 (E/Z)-Mirin Inhibitor 99.22% Unkown
HY-149972 Antitumor agent-96 Inducer / Unkown
HY-RS11602 RAD50 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18404 Rad50 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24885 Rad50 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rad50 NCBI NCBI:10111