PLBD2 - phospholipase B domain containing 2 Gene

Also Known as P76

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 196463

About PLBD2

Cytogenetic location: 12q24.13 Genomic coordinates (GRCh38): 12:113,358,587-113,391,629 (from NCBI)

This gene has 4 transcripts (splice variants), 193 orthologues and 1 paralogue. Ubiquitous expression in adrenal (RPKM 36.9), ovary (RPKM 20.4) and 25 other tissues.

Summary

Predicted to enable Phospholipase activity. Predicted to be involved in phospholipid catabolic process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

PLBD2 Products (2)

mRNA	Protein	Name
NM_001159727.2	NP_001153199.1	putative phospholipase B-like 2 isoform 2 precursor
NM_173542.4	NP_775813.2	putative phospholipase B-like 2 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLBD2 Protein Structure

Phospholip_B

0
100
200
300
400
500
589 a.a.

Protein Preferred Names	Protein Names
putative phospholipase B-like 2	76 kDa protein

PLBD2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PLBD2	Q8NHP8	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	PLBD2	Q8NHP8	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	PLBD2	Q8NHP8	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PLBD2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77148	PLBD2 Protein, Human (HEK293, His)	Q8NHP8-1 (I42-D589)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Gallbladder Papillomatosis
Sea-Blue Histiocyte Disease	Sea-Blue Histiocytosis Sea-Blue Histiocyte Syndrome Histiocytosis, Sea-Blue Inherited Lipemic Splenomegaly SBHD
Gm1-Gangliosidosis, Type Iii	Gm1 Gangliosidosis Type 3 GM1G3 Gangliosidosis, Generalized Gm1, Type 3 Adult-Onset Gm1 Gangliosidosis Gangliosidosis Gm1 Type 3 Gangliosidosis Generalized Gm1 Chronic Type Gangliosidosis, Generalized Gm1, Adult Type Gangliosidosis, Generalized Gm1, Chronic Type Gangliosidosis, Generalized Gm1, Type Iii Adult Gm1 Gangliosidosis Beta-Galactosidase Deficiency Type 3 Gm1-Gangliosidosis 3 Gangliosidosis Generalized Gm1 Type 3 Gm1-Gangliosidosis Generalized Adult Type Gangliosidosis, Gm1 Type Iii
Gaucher Disease, Type Iiic	Gaucher Disease-Ophthalmoplegia-Cardiovascular Calcification Syndrome Gaucher-Like Disease GD3C Gaucher'S Disease Type Iiic Cardiovascular Gaucher Disease Gaucher Disease Type 3c Gaucher Disease 3c Pseudo-Gaucher Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10651	PLBD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17839	Plbd2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24307	Plbd2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PLBD2	MGD	MGI:1919022
Canis familiaris	PLBD2	VGNC	VGNC:44643
Felis catus	PLBD2	VGNC	VGNC:64207
Macaca mulatta	PLBD2	VGNC	VGNC:76122
Rattus norvegicus	PLBD2	RGD	RGD:708461
Bos taurus	PLBD2	VGNC	VGNC:32979
Others	PLBD2	NCBI