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Rbpj - recombination signal binding protein for immunoglobulin kappa J region Gene

Also Known as CBF1; RBP-J; RBPjk; Igkjrb; Rbpsuh; Igkrsbp; RBP-Jkappa; RBP-J kappa

Species: Mus musculus

Gene Type: protein coding

Gene ID: 19664

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein N-terminus binding activity. Involved in several processes, including circulatory system development; positive regulation of signal transduction; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; blood vessel morphogenesis; and regulation of transcription, DNA-templated. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including early conceptus; genitourinary system; neural ectoderm; paraxial mesenchyme; and retina. Used to study aortic valve disease. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and dilated cardiomyopathy. Orthologous to human RBPJ (recombination signal binding protein for immunoglobulin kappa J region). [provided by Alliance of Genome Resources, Apr 2022]

Rbpj Products (5)

mRNA	Protein	Name
NM_001080927.2	NP_001074396.1	recombining binding protein suppressor of hairless isoform 2
NM_001080928.1	NP_001074397.1	recombining binding protein suppressor of hairless isoform 3
NM_001277116.1	NP_001264045.1	recombining binding protein suppressor of hairless isoform 4
NM_001359152.1	NP_001346081.1	recombining binding protein suppressor of hairless isoform 5
NM_009035.5	NP_033061.3	recombining binding protein suppressor of hairless isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	9111338	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12730124	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17658279	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	17015435	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8749394	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17658278	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within B cell differentiation	IMP IMP: Inferred from mutant phenotype	11967543	MGI
acts upstream of or within Notch signaling pathway	IGI IGI: Inferred from genetic interaction	25406395	MGI
acts upstream of or within Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	14701881	MGI
involved in Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	15466160	MGI
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	15466160	MGI
involved in aortic valve development	IMP IMP: Inferred from mutant phenotype	26491108	MGI
involved in arterial endothelial cell fate commitment	IMP IMP: Inferred from mutant phenotype	15466160	MGI
acts upstream of or within artery morphogenesis	IMP IMP: Inferred from mutant phenotype	23117660	MGI
involved in atrioventricular canal development	IMP IMP: Inferred from mutant phenotype	14701881	MGI
acts upstream of or within auditory receptor cell fate commitment	IMP IMP: Inferred from mutant phenotype	19154718	MGI
involved in blood vessel endothelial cell fate specification	IGI IGI: Inferred from genetic interaction	15466160	MGI
involved in blood vessel lumenization	IMP IMP: Inferred from mutant phenotype	15466160	MGI
involved in blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	15466160	MGI
involved in cardiac left ventricle morphogenesis	IMP IMP: Inferred from mutant phenotype	21493891	MGI
involved in cardiac muscle cell myoblast differentiation	IMP IMP: Inferred from mutant phenotype	21311046	MGI
acts upstream of cell differentiation	IMP IMP: Inferred from mutant phenotype	17015435	MGI
acts upstream of or within cell fate commitment	IMP IMP: Inferred from mutant phenotype	17015435	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	15509736	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17079689	MGI
acts upstream of or within club cell differentiation	IMP IMP: Inferred from mutant phenotype	22797898	MGI
acts upstream of or within defense response to bacterium	IMP IMP: Inferred from mutant phenotype	11967543	MGI
involved in dorsal aorta morphogenesis	IMP IMP: Inferred from mutant phenotype	15466160	MGI
involved in endocardium development	IMP IMP: Inferred from mutant phenotype	17336907	MGI
involved in endocardium morphogenesis	IMP IMP: Inferred from mutant phenotype	14701881	MGI
acts upstream of or within epidermal cell fate specification	IMP IMP: Inferred from mutant phenotype	17079689	MGI
acts upstream of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	15509736	MGI
acts upstream of or within epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	14701881	MGI
involved in epithelial to mesenchymal transition involved in endocardial cushion formation	IMP IMP: Inferred from mutant phenotype	14701881	MGI
acts upstream of or within hair follicle maturation	IMP IMP: Inferred from mutant phenotype	17079689	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	14701881	MGI
acts upstream of or within hemopoiesis	IMP IMP: Inferred from mutant phenotype	15689374	MGI
acts upstream of or within humoral immune response	IMP IMP: Inferred from mutant phenotype	17658279	MGI
acts upstream of or within inflammatory response to antigenic stimulus	IMP IMP: Inferred from mutant phenotype	17658279	MGI
acts upstream of or within interleukin-4 production	IMP IMP: Inferred from mutant phenotype	17658279	MGI
acts upstream of or within keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	17079689	MGI
involved in labyrinthine layer blood vessel development	IMP IMP: Inferred from mutant phenotype	15466160	MGI
acts upstream of or within myeloid dendritic cell differentiation	IMP IMP: Inferred from mutant phenotype	23913046	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9111338	MGI
acts upstream of or within negative regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	10476967	MGI
involved in negative regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	25038826	MGI
involved in negative regulation of ossification	IMP IMP: Inferred from mutant phenotype	21493891	MGI
acts upstream of or within negative regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	17079689	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	14701881	MGI
acts upstream of or within neuron differentiation	IMP IMP: Inferred from mutant phenotype	9102301	MGI
involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	14701881	MGI
acts upstream of or within pituitary gland development	IMP IMP: Inferred from mutant phenotype	17015435	MGI
involved in positive regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	17336907	MGI
involved in positive regulation of ERBB signaling pathway	IMP IMP: Inferred from mutant phenotype	17336907	MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	22711842	MGI
involved in positive regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	17336907	MGI
involved in positive regulation of cell proliferation involved in heart morphogenesis	IMP IMP: Inferred from mutant phenotype	17336907	MGI
involved in positive regulation of ephrin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17336907	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	15509736	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23117660	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12730124	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	14701881	MGI
acts upstream of or within positive regulation of transcription of Notch receptor target	IGI IGI: Inferred from genetic interaction	12794108	MGI
involved in pulmonary valve development	IMP IMP: Inferred from mutant phenotype	26491108	MGI
involved in regulation of cell adhesion involved in heart morphogenesis	IMP IMP: Inferred from mutant phenotype	14701881	MGI
acts upstream of or within regulation of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	25406395	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	9102301	MGI
acts upstream of or within regulation of timing of cell differentiation	IMP IMP: Inferred from mutant phenotype	17015435	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15689374	MGI
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21311046	MGI
acts upstream of or within sebaceous gland development	IMP IMP: Inferred from mutant phenotype	17079689	MGI
acts upstream of or within secondary heart field specification	IGI IGI: Inferred from genetic interaction	22711842	MGI
acts upstream of or within secondary heart field specification	IMP IMP: Inferred from mutant phenotype	22711842	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	21402740	MGI
acts upstream of or within somitogenesis	IMP IMP: Inferred from mutant phenotype	19779553	MGI
acts upstream of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	17079689	MGI
involved in ventricular septum morphogenesis	IMP IMP: Inferred from mutant phenotype	26491108	MGI
involved in ventricular trabecula myocardium morphogenesis	IMP IMP: Inferred from mutant phenotype	17336907	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	9102301	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	17938243	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
recombining binding protein suppressor of hairless	J-kappa recombination signal binding protein Jkappa recombination signal binding protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-137471	RBPJ Inhibitor-1	Inhibitor	99.87%	Unkown
HY-116940	Sm4	Inhibitor	99.01%	Unkown
HY-RS11772	RBPJ Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17271	Rbpj Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23725	Rbpj Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rbpj	NCBI	NCBI:3516