Rnf4 - ring finger protein 4 Gene

Also Known as SNURF; Gtrgeo8

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19822

Summary

This gene encodes a small nuclear RING finger protein that mediates ubiquitylation of polysumoylated proteins. Deficiency of the encoded protein in mice leads to embryonic lethality and global DNA hypermethylation. A similar protein in humans is required for arsenic-induced degradation of promyelocytic leukemia protein in acute promyelocytic leukemia. Alternative splicing of this gene results in multiple transcript variants. A pseudogene for this gene has been identified on chromosome 10. [provided by RefSeq, Jan 2015]

Rnf4 Products (3)

mRNA Protein Name
NM_001304269.1 NP_001291198.1 E3 ubiquitin-protein ligase RNF4
NM_001304270.1 NP_001291199.1 E3 ubiquitin-protein ligase RNF4
NM_011278.5 NP_035408.1 E3 ubiquitin-protein ligase RNF4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10822263 MGI
enables transcription factor binding IPI
IPI: Inferred from physical interaction
10849425 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10849425 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10822263 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10822263 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF4

  • E3 ubiquitin ligase RNF4

  • RING-type E3 ubiquitin transferase RNF4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-143346 CCW16 98.73% Unkown
HY-184506 R4VPL3-1 / Unkown
HY-184508 E3 ligase Ligand 81 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rnf4 NCBI NCBI:6047