S100a9 - S100 calcium binding protein A9 (calgranulin B) Gene

Also Known as p14; Cagb; GAGB; L1Ag; BEE22; MRP14; 60B8Ag

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20202

Summary

Predicted to enable calcium ion binding activity and calcium-dependent protein binding activity. Involved in peptidyl-cysteine S-nitrosylation; positive regulation of blood coagulation; and regulation of translation. Acts upstream of or within several processes, including actin Cytoskeleton reorganization; astrocyte development; and regulation of Integrin biosynthetic process. Predicted to be located in cell junction; cytosol; and nucleoplasm. Predicted to be active in cytoplasm; extracellular space; and nucleus. Is expressed in several structures, including jaw; liver; otic capsule; skeleton; and spleen red pulp. Human ortholog(s) of this gene implicated in myocarditis. Orthologous to human S100A9 (S100 calcium binding protein A9). [provided by Alliance of Genome Resources, Apr 2022]

S100a9 Products (4)

mRNA	Protein	Name
NM_001281852.1	NP_001268781.1	protein S100-A9
NM_009114.3	NP_033140.1	protein S100-A9
NM_001281852.1	NP_001268781.1	protein S100-A9
NM_009114.3	NP_033140.1	protein S100-A9

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	12529407	MGI
acts upstream of or within astrocyte development	IGI IGI: Inferred from genetic interaction	22577135	MGI
acts upstream of or within leukocyte chemotaxis	IMP IMP: Inferred from mutant phenotype	12529407	MGI
acts upstream of peptide secretion	IDA IDA: Inferred from direct assay	18820689	MGI
acts upstream of peptide secretion	IMP IMP: Inferred from mutant phenotype	18820689	MGI
involved in peptidyl-cysteine S-nitrosylation	IMP IMP: Inferred from mutant phenotype	25417112	MGI
involved in positive regulation of blood coagulation	IMP IMP: Inferred from mutant phenotype	24691441	MGI
acts upstream of or within positive regulation of peptide secretion	IDA IDA: Inferred from direct assay	18820689	MGI
acts upstream of or within positive regulation of peptide secretion	IMP IMP: Inferred from mutant phenotype	18820689	MGI
acts upstream of or within regulation of integrin biosynthetic process	IMP IMP: Inferred from mutant phenotype	12529407	MGI
involved in regulation of translation	IMP IMP: Inferred from mutant phenotype	25417112	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in cornified envelope	IDA IDA: Inferred from direct assay	26644517	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein S100-A9	S100 calcium-binding protein A9 leukocyte L1 complex heavy chain migration inhibitory factor-related protein 14

Recombinant S100a9 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74583	S100A9 Protein, Mouse (His)	P31725 (A2-K113)	≥ 95%, as determined by reducing SDS-PAGE.

S100a9 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82149	S100 alpha9 Antibody (YA1894)	WB, IHC-F, IHC-P, ICC/IF	Mouse
HY-P82149A	S100 alpha9 Antibody (YA1894)(PBS only)	WB, IHC-F, IHC-P, ICC/IF	Mouse

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10528	Tasquinimod	Modulator	99.70%	Phase 3
HY-100442	Paquinimod	Inhibitor	99.90%	Phase 2

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100442S1	Paquinimod-d5-1	Inhibitor	98.19%	Unkown
HY-10528S	Tasquinimod-d3	Modulator	99.34%	Unkown
HY-RS12386	S100A9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16579	S100a9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-178053	AHR agonist 10		/	Unkown
HY-181576	ROCK2-IN-14	Inhibitor	/	Unkown
HY-100442S	Paquinimod-d5	Inhibitor	/	Unkown
HY-RS23013	S100a9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991517	BI-836858		95.81%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	S100a9	NCBI	NCBI:6280