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Scx - scleraxis Gene

Also Known as Scl; Bhlha41

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20289

Summary

This gene encodes a basic helix-loop-helix type transcription factor involved in mesoderm and heart valve formation. The encoded protein is expressed during embryonic development of tendons and ligaments. The gene product regulates Collagen type I gene expression in cardiac fibroblasts and myofibroblasts, and it may play a role in myocardial remodeling. The protein is expressed in the scar area of the adult heart following myocardial infarction. [provided by RefSeq, Feb 2010]

Scx Products (1)

mRNA	Protein	Name
NM_198885.3	NP_942588.1	basic helix-loop-helix transcription factor scleraxis

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	7743923	MGI
contributes to E-box binding	IDA IDA: Inferred from direct assay	19828133	MGI
enables E-box binding	IDA IDA: Inferred from direct assay	7743923	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7743923	MGI
enables bHLH transcription factor binding	IPI IPI: Inferred from physical interaction	19828133	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17430895	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7743923	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9328840	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	20059955	MGI
involved in DNA-templated transcription	IDA IDA: Inferred from direct assay	9328840	MGI
involved in cell differentiation	IMP IMP: Inferred from mutant phenotype	18802027	MGI
involved in cellular response to BMP stimulus	IEP IEP: Inferred from expression pattern	9328840	MGI
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	21625049	MGI
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	9328840	MGI
involved in chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	20059955	MGI
involved in collagen fibril organization	IMP IMP: Inferred from mutant phenotype	18802027	MGI
involved in deltoid tuberosity development	IMP IMP: Inferred from mutant phenotype	17567668	MGI
involved in embryonic skeletal system development	IEP IEP: Inferred from expression pattern	7743923	MGI
involved in endochondral ossification	IMP IMP: Inferred from mutant phenotype	20059955	MGI
involved in face morphogenesis	IEP IEP: Inferred from expression pattern	18498113	MGI
involved in heart valve formation	IMP IMP: Inferred from mutant phenotype	18802027	MGI
involved in heart valve morphogenesis	IMP IMP: Inferred from mutant phenotype	18802027	MGI
involved in mesoderm formation	IMP IMP: Inferred from mutant phenotype	10477299	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	18802027	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	10477299	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	7743923	MGI
involved in positive regulation of cartilage development	IMP IMP: Inferred from mutant phenotype	10477299	MGI
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	10477299	MGI
involved in positive regulation of collagen biosynthetic process	IDA IDA: Inferred from direct assay	19362560	MGI
involved in positive regulation of collagen biosynthetic process	IMP IMP: Inferred from mutant phenotype	18802027	MGI
involved in positive regulation of gastrulation	IMP IMP: Inferred from mutant phenotype	10477299	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	19362560	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18802027	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7743923	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	17430895	MGI
involved in regulation of cartilage development	IMP IMP: Inferred from mutant phenotype	18802027	MGI
involved in sclerotome development	IEP IEP: Inferred from expression pattern	7743923	MGI
acts upstream of or within skeletal muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	22147266	MGI
involved in tendon cell differentiation	IMP IMP: Inferred from mutant phenotype	17567668	MGI
involved in tendon development	IMP IMP: Inferred from mutant phenotype	17567668	MGI
involved in tendon formation	IMP IMP: Inferred from mutant phenotype	14568104	MGI
involved in tissue homeostasis	IMP IMP: Inferred from mutant phenotype	18802027	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	19362560	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	19828133	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
basic helix-loop-helix transcription factor scleraxis

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-158231	Polyether F127 Diacrylate	Activator	/	Unkown
HY-RS12574	SCX Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22084	Scx Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28604	Scx Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W667933	S-Propyl-L-cysteine sulfoxide		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Scx	NCBI	NCBI:642658