Ptk6 - PTK6 protein tyrosine kinase 6 Gene

Also Known as BRK; Sik; tks; Tksk

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20459

Summary

Predicted to enable identical protein binding activity; non-membrane spanning protein tyrosine kinase activity; and signaling receptor binding activity. Involved in intestinal epithelial cell differentiation and negative regulation of growth. Located in nucleus. Is expressed in several structures, including gut; liver; and skin. Orthologous to human PTK6 (protein tyrosine kinase 6). [provided by Alliance of Genome Resources, Apr 2022]

Ptk6 Products (2)

mRNA Protein Name
NM_001356304.1 NP_001343233.1 protein-tyrosine kinase 6 isoform 2
NM_009184.2 NP_033210.1 protein-tyrosine kinase 6 isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in intestinal epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
16782882 MGI
involved in negative regulation of growth IMP
IMP: Inferred from mutant phenotype
16782882 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
12200423 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein-tyrosine kinase 6

  • src-related intestinal kinase

  • tyrosine kinase identified from skin

Recombinant Ptk6 Proteins

Cat. No. Product Name Accession Purity
HY-P72856 Brk Protein, Mouse (Active, sf9, His-GST) Q64434 (M1-V451) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (21)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-110244 Tilfrinib Inhibitor 99.39% Unkown
HY-N0616 Trifolirhizin 98.37% Unkown
HY-108333 SB-633825 Inhibitor 98.05% Unkown
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-147219A SIAIS164018 hydrochloride 98.06% Unkown
HY-171830 MS105 98.27% Unkown
HY-115514A BRK inhibitor P21d hydrochloride Inhibitor 99.77% Unkown
HY-122664 XMU-MP-2 99.29% Unkown
HY-139660 PTK6 ligand-1 95.03% Unkown
HY-147219 SIAIS164018 / Unkown
HY-RS11403 PTK6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-163214 (S)-PROTAC PTK6 ligand-1-(2S,4R)-O-CH2-O-hygric acid / Unkown
HY-163215 (S)-PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc / Unkown
HY-163216 PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc / Unkown
HY-163217 PROTAC PTK6 ligand-2,7-diazaspiro[3.5]nonane-Boc / Unkown
HY-163218 PROTAC PTK6 ligand-1-(2S,4R)-O-CH2-O-hygric acid / Unkown
HY-163224 (S)-PROTAC PTK6 ligand-O-C2-O-piperidine-Boc / Unkown
HY-163228 PROTAC PTK6 ligand-O-C2-O-piperidine-Boc / Unkown
HY-178460 BRK/PTK6-IN-1 Inhibitor / Unkown
HY-RS17542 Ptk6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24000 Ptk6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptk6 NCBI NCBI:5753