PTK6 - protein tyrosine kinase 6 Gene

Homo sapiens

Also known as BRK

Gene ID: 5753 | Gene type: protein coding

About PTK6

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,528,001-63,537,376 (from NCBI)

This gene has 2 transcripts (splice variants), 175 orthologues, 32 paralogues and is associated with 50 phenotypes. Biased expression in esophagus (RPKM 27.3), skin (RPKM 21.0) and 9 other tissues.

Summary

The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

PTK6 Products(2)

mRNA	Protein	Name
NM_001256358.2	NP_001243287.1	protein-tyrosine kinase 6 isoform 2
NM_005975.4	NP_005966.1	protein-tyrosine kinase 6 isoform 1

PTK6 Protein Structure

Pkinase_Tyr

0
100
200
300
350 a.a.

Protein Preferred Names

Protein Names

protein-tyrosine kinase 6

PTK6 protein tyrosine kinase 6

Recombinant PTK6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75470	Brk Protein, Human (sf9, GST)	Q13882-1 (M1-T451)	≥95%

Related Diseases

Diseases

Alias

Ovary Serous Adenocarcinoma

Malignant Ovarian Serous Tumor

Serous Carcinoma Of Ovary

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Charge Syndrome

Charge Association	Hall-Hittner Syndrome
Charge Association--Coloboma, Heart Anomaly, Choanal Atresia, Retardation, Genital And Ear Anomalies	Hhs
Coloboma, Heart Anomaly, Choanal Atresia, Restriction Of Growth And Development, Genital And Ear Anomalies	Coloboma-Heart Defects-Atresia Choanae-Retardation Of Growth And Development-Genitourinary Problems-Ear Abnormalities Syndrome
CHARGES

Aggressive Systemic Mastocytosis

Asm	Lymphadenopathic Mastocytosis With Eosinophilia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108333	SB-633825	Inhibitor	98.52%	Unkown
HY-110244	Tilfrinib	Inhibitor	99.69%	Unkown
HY-115514A	BRK inhibitor P21d hydrochloride	Inhibitor	≥98.0%	Unkown
HY-139660	PROTAC PTK6 ligand-1		95.03%	Unkown
HY-148065	FMF-06-098-1		/	Unkown
HY-163214	(S)-PROTAC PTK6 ligand-1-(2S,4R)-O-CH2-O-hygric acid		/	Unkown
HY-163215	(S)-PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc		/	Unkown
HY-163216	PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc		/	Unkown
HY-163217	PROTAC PTK6 ligand-2,7-diazaspiro[3.5]nonane-Boc		/	Unkown
HY-163218	PROTAC PTK6 ligand-1-(2S,4R)-O-CH2-O-hygric acid		/	Unkown
HY-163224	(S)-PROTAC PTK6 ligand-O-C2-O-piperidine-Boc		/	Unkown
HY-163228	PROTAC PTK6 ligand-O-C2-O-piperidine-Boc		/	Unkown
HY-RS11403	PTK6 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PTK6	VGNC	VGNC:84902
Felis catus	PTK6	VGNC	VGNC:81161
Mus musculus	PTK6	MGD	MGI:99683
Bos taurus	PTK6	VGNC	VGNC:33520
Rattus norvegicus	PTK6	RGD	RGD:1309098
Others	PTK6	NCBI

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