Spink1 - serine peptidase inhibitor, Kazal type 1 Gene

Also Known as p12; Spink3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20730

Summary

Enables serine-type endopeptidase inhibitor activity. Acts upstream of or within several processes, including negative regulation of cellular protein metabolic process; negative regulation of nitric oxide mediated signal transduction; and regulation of calcium ion transport. Located in extracellular space. Is expressed in embryo ectoderm; embryo endoderm; genitourinary system; gut; and yolk sac. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to human SPINK1 (serine peptidase inhibitor Kazal type 1). [provided by Alliance of Genome Resources, Apr 2022]

Spink1 Products (1)

mRNA Protein Name
NM_009258.5 NP_033284.1 serine protease inhibitor Kazal-type 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables peptidase inhibitor activity IDA
IDA: Inferred from direct assay
3428272 MGI
enables serine-type endopeptidase inhibitor activity IDA
IDA: Inferred from direct assay
18715980 MGI
enables serine-type endopeptidase inhibitor activity IMP
IMP: Inferred from mutant phenotype
20110462 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of calcium ion import IDA
IDA: Inferred from direct assay
2430282 MGI
acts upstream of or within negative regulation of nitric oxide mediated signal transduction IDA
IDA: Inferred from direct assay
22228629 MGI
acts upstream of or within negative regulation of peptidase activity IDA
IDA: Inferred from direct assay
3428272 MGI
acts upstream of or within negative regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
22228629 MGI
acts upstream of or within negative regulation of serine-type endopeptidase activity IDA
IDA: Inferred from direct assay
22228629 MGI
acts upstream of or within negative regulation of serine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
20110462 MGI
acts upstream of nitric oxide mediated signal transduction IDA
IDA: Inferred from direct assay
22228629 MGI
acts upstream of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
22228629 MGI
acts upstream of or within regulation of acrosome reaction IDA
IDA: Inferred from direct assay
22228629 MGI
acts upstream of or within regulation of store-operated calcium entry IDA
IDA: Inferred from direct assay
22228629 MGI
acts upstream of or within sperm capacitation IDA
IDA: Inferred from direct assay
22228629 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
18715980 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine protease inhibitor Kazal-type 1

  • prostatic secretory glycoprotein

  • serine peptidase inhibitor, Kazal type 3

  • serine protease inhibitor Kazal-type 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13679 SPINK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19269 Spink1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25758 Spink1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spink1 NCBI NCBI:6690