Btla - B and T lymphocyte associated Gene

Also Known as A630002H24

Species: Mus musculus

Gene Type: protein coding
Gene ID: 208154

Summary

Enables signaling receptor activity. Acts upstream of or within immune response-regulating cell surface receptor signaling pathway; negative regulation of B cell proliferation; and negative regulation of alpha-beta T cell proliferation. Located in external side of plasma membrane. Is integral component of plasma membrane. Orthologous to human BTLA (B and T lymphocyte associated). [provided by Alliance of Genome Resources, Apr 2022]

Btla Products (2)

mRNA Protein Name
NM_001037719.2 NP_001032808.2 B- and T-lymphocyte attenuator isoform 1 precursor
NM_177584.3 NP_808252.1 B- and T-lymphocyte attenuator isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12796776 MGI
enables signaling receptor activity IGI
IGI: Inferred from genetic interaction
12920180 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
15568026 MGI
acts upstream of or within immune response-regulating cell surface receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15568026 MGI
acts upstream of or within negative regulation of B cell proliferation IMP
IMP: Inferred from mutant phenotype
12796776 MGI
acts upstream of or within negative regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
12796776 MGI
acts upstream of or within negative regulation of alpha-beta T cell proliferation IMP
IMP: Inferred from mutant phenotype
15568026 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
15568026 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12796776 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

B- and T-lymphocyte attenuator

  • B- and T-lymphocyte-associated protein

Recombinant Btla Proteins

Cat. No. Product Name Accession Purity
HY-P75467 BTLA/CD272 Protein, Mouse (HEK293, hFc) Q32MV9 (E30-G176,(K173E)) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P78246 BTLA/CD272 Protein, Mouse (HEK293, His) Q32MV9/AAI08964.1 (E30-G176) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99961 Tifcemalimab Inhibitor 96.02% Phase 3
HY-P990773 Venanprubart Inhibitor 98.00% Phase 2

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-159885 MG-B-28 Inhibitor / Unkown
HY-P10851 HVEM(14-39) Inducer / Unkown
HY-RS01669 BTLA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16938 Btla Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23381 Btla Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990298 Anti-Mouse BTLA/CD272 Antibody (6A6) Inhibitor 95.00% Unkown
HY-P991038 Zadoprubart 99% Unkown
HY-P991833 Anti-Mouse BTLA/CD272 Antibody (PK18.6) Inhibitor / Unkown
HY-P991835 Anti-Mouse BTLA/CD272 Antibody (PJ196) Inhibitor / Unkown
HY-P992182 ANB032 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Btla NCBI NCBI:151888