BTLA - B and T lymphocyte associated Gene

Also Known as BTLA1; CD272

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 151888

About BTLA

Cytogenetic location: 3q13.2 Genomic coordinates (GRCh38): 3:112,463,966-112,499,624 (from NCBI)

This gene has 4 transcripts (splice variants) and 87 orthologues. Biased expression in lymph node (RPKM 5.9), appendix (RPKM 3.2) and 7 other tissues.

Summary

This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis. [provided by RefSeq, Aug 2011]

BTLA Products (2)

mRNA Protein Name
NM_001085357.2 NP_001078826.1 B- and T-lymphocyte attenuator isoform 2
NM_181780.4 NP_861445.4 B- and T-lymphocyte attenuator isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
27152329 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BTLA Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (47 - 131)

  • 0
  • 100
  • 200
  • 289 a.a.
Protein Preferred Names Protein Names

B- and T-lymphocyte attenuator

  • B- and T-lymphocyte-associated protein

Recombinant BTLA Proteins

Cat. No. Product Name Accession Purity
HY-P7678 BTLA/CD272 Protein, Human (HEK293, His) Q7Z6A9-2 (K31-L150) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7679 BTLA/CD272 Protein, Human (HEK293, Fc) Q7Z6A9-2 (K31-L150) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72030 BTLA/CD272 Protein, Human (HEK293, hFc) Q7Z6A9-1 (K31-S150) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78078 BTLA/CD272 Protein, Human (Biotinylated, HEK293, His-Avi) Q7Z6A9-1 (K31-S150) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78394 BTLA/CD272 Protein, Human (HEK293, His-Avi) Q7Z6A9-1 (K31-S150) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78924 BTLA/CD272 Protein, Human (Biotinylated, HEK293, Fc-Avi) Q7Z6A9-1/AAP44003 (K31-S150) ≥ 95%, as determined by reducing SDS-PAGE.

BTLA Antibodies

Cat. No. Product Name Application Reactivity
HY-P81619 BTLA Antibody (YA1364) FC, ELISA Human

Related Diseases

Diseases Alias
Rheumatoid Arthritis

  • RA

  • Arthritis, Rheumatoid

  • Rheumatoid Arthritis, Susceptibility To

  • Arthritis Or Polyarthritis, Rheumatic

  • Atrophic Arthritis

  • Rheumatism Arthritis

  • Rheumatoid Polyarthritis
Arthritis

  • Inflammatory Joint Disease

  • Inflammatory Disorder Of Joint
Ezb Diffuse Large B-Cell Lymphoma

  • Ezb Dlbcl

  • Doid:0081065
Cone-Rod Dystrophy 2

  • Cone-Rod Dystrophy

  • CORD2

  • Cone-Rod Retinal Dystrophy

  • Rcrd2

  • Cone-Rod Retinal Dystrophy 2

  • Crd2

  • Cord

  • Crd

  • Retinal Cone-Rod Dystrophy

  • Cone-Rod Retinal Dystrophy-2

  • Retinal Cone-Rod Dystrophy 2

  • Tapetoretinal Degeneration

  • Cone-Rod Degeneration

  • Cone Rod Dystrophy

  • Dystrophy, Cone-Rod

  • Dystrophy, Cone-Rod, Type 2

  • Retinitis Pigmentosa

  • Retinitis Pigmentosa 2

  • Progressive Cone-Rod Dystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99961 Tifcemalimab Inhibitor 96.02% Phase 3
HY-P990773 Venanprubart Inhibitor 98.00% Phase 2

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-159885 MG-B-28 Inhibitor / Unkown
HY-P10851 HVEM(14-39) Inducer / Unkown
HY-RS01669 BTLA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16938 Btla Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23381 Btla Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990298 Anti-Mouse BTLA/CD272 Antibody (6A6) Inhibitor 95.00% Unkown
HY-P991038 Zadoprubart 99% Unkown
HY-P991833 Anti-Mouse BTLA/CD272 Antibody (PK18.6) Inhibitor / Unkown
HY-P991835 Anti-Mouse BTLA/CD272 Antibody (PJ196) Inhibitor / Unkown
HY-P992182 ANB032 / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus BTLA RGD RGD:1303280
Canis familiaris BTLA VGNC VGNC:38561
Macaca mulatta BTLA VGNC VGNC:70358
Bos taurus BTLA VGNC VGNC:26602
Felis catus BTLA VGNC VGNC:60206
Mus musculus BTLA MGD MGI:2658978
Others BTLA NCBI