BTLA - B and T lymphocyte associated Gene

Homo sapiens

Also known as BTLA1; CD272

Gene ID: 151888 | Gene type: protein coding

About BTLA

Cytogenetic location: 3q13.2 Genomic coordinates (GRCh38): 3:112,463,966-112,499,624 (from NCBI)

This gene has 4 transcripts (splice variants) and 87 orthologues. Biased expression in lymph node (RPKM 5.9), appendix (RPKM 3.2) and 7 other tissues.

Summary

This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis. [provided by RefSeq, Aug 2011]

BTLA Products(2)

mRNA	Protein	Name
NM_001085357.2	NP_001078826.1	B- and T-lymphocyte attenuator isoform 2
NM_181780.4	NP_861445.4	B- and T-lymphocyte attenuator isoform 1 precursor

BTLA Protein Structure

Ig_2

0
100
200
289 a.a.

Protein Preferred Names

Protein Names

B- and T-lymphocyte attenuator

B- and T-lymphocyte-associated protein

Recombinant BTLA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7678	BTLA/CD272 Protein, Human (HEK293, His)	Q7Z6A9-2 (K31-L198)	≥95%
HY-P7679	BTLA/CD272 Protein, Human (168a.a, HEK293, Fc)	Q7Z6A9-2 (K31-L198)	≥95%
HY-P72030	BTLA/CD272 Protein, Human (HEK293, hFc-Myc)	Q7Z6A9 (K31-S150)	≥95%
HY-P72858	BTLA/CD272 Protein, Human (104a.a, HEK293, Fc)	Q7Z6A9-2 (K31-T134)	≥95%
HY-P78078	BTLA/CD272 Protein, Human (Biotinylated, HEK293, His-Avi)	Q7Z6A9 (K31-S150)	≥95%
HY-P78394	BTLA/CD272 Protein, Human (HEK293, His-Avi)	Q7Z6A9 (K31-S150)	≥95%
HY-P78924	BTLA/CD272 Protein, Human (Biotinylated, HEK293, Fc-Avi)	AAP44003 (K31-S150)	≥95%

Related Diseases

Diseases

Alias

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Ezb Diffuse Large B-Cell Lymphoma

Ezb Dlbcl

Doid:0081065

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108813	Belatacept	Inhibitor	98.00%	Unkown

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99961	Tifcemalimab	Inhibitor	95.00%	Phase 3

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01669	BTLA Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	BTLA	RGD	RGD:1303280
Canis familiaris	BTLA	VGNC	VGNC:38561
Macaca mulatta	BTLA	VGNC	VGNC:70358
Bos taurus	BTLA	VGNC	VGNC:26602
Felis catus	BTLA	VGNC	VGNC:60206
Mus musculus	BTLA	MGD	MGI:2658978
Others	BTLA	NCBI

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