Enpp3 - ectonucleotide pyrophosphatase/phosphodiesterase 3 Gene

Also Known as CD203c

Species: Mus musculus

Gene Type: protein coding
Gene ID: 209558

Summary

Enables nucleoside-triphosphate diphosphatase activity. Involved in several processes, including basophil activation involved in immune response; negative regulation of mast cell activation involved in immune response; and negative regulation of mast cell proliferation. Located in external side of plasma membrane. Orthologous to human ENPP3 (ectonucleotide pyrophosphatase/phosphodiesterase 3). [provided by Alliance of Genome Resources, Apr 2022]

Enpp3 Products (1)

mRNA Protein Name
NM_134005.2 NP_598766.2 ectonucleotide pyrophosphatase/phosphodiesterase family member 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nucleoside triphosphate diphosphatase activity IMP
IMP: Inferred from mutant phenotype
25692702 MGI
Biological Process GO Annotation Evidence References Source
involved in ATP metabolic process IMP
IMP: Inferred from mutant phenotype
25692702 MGI
involved in basophil activation involved in immune response IMP
IMP: Inferred from mutant phenotype
25692702 MGI
involved in negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
25692702 MGI
involved in negative regulation of mast cell activation involved in immune response IMP
IMP: Inferred from mutant phenotype
25692702 MGI
involved in negative regulation of mast cell proliferation IMP
IMP: Inferred from mutant phenotype
25692702 MGI
involved in phosphate ion homeostasis IDA
IDA: Inferred from direct assay
21490328 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
25692702 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ectonucleotide pyrophosphatase/phosphodiesterase family member 3

  • E-NPP 3

  • PD-Ibeta

  • phosphodiesterase I beta

  • phosphodiesterase I/nucleotide pyrophosphatase 3

Recombinant Enpp3 Proteins

Cat. No. Product Name Accession Purity
HY-P78705 ENPP-3 Protein, Mouse (HEK293, His) Q6DYE8 (R46-I874) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-171544 AGS-16C3F 99.81% Phase 2

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-169804 ENPP3 Inhibitor 1 Inhibitor 99.43% Unkown
HY-158791 Enpp-1-IN-21 Inhibitor 99.07% Unkown
HY-149465 STF-1623 Inhibitor 99.90% Unkown
HY-147998 Enpp-1-IN-13 Inhibitor / Unkown
HY-172527 CD73-IN-20 Inhibitor / Unkown
HY-172528 Enpp-1/3-IN-1 Inhibitor / Unkown
HY-175478 Enpp-1-IN-27 / Unkown
HY-181667 Enpp-1-IN-30 Inhibitor / Unkown
HY-184200 Enpp-1-IN-32 / Unkown
HY-RS04389 ENPP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17607 Enpp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24067 Enpp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991706 Nelvutamig Inhibitor 97.76% Unkown
HY-P991705 Nebaprubart Inhibitor 96.95% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Enpp3 NCBI NCBI:5169