2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Phosphodiesterase (PDE) STING
  4. STF-1623

STF-1623 is a highly potent ENPP1 inhibitor with an IC50 of 0.6 nM. STF-1623 inhibits ENPP1, activates tumor-specific STING signaling. STF-1623 blocks breast, pancreatic, colon, and brain cancer progression.

For research use only. We do not sell to patients.

STF-1623

STF-1623 Chemical Structure

CAS No. : 2298391-60-1

Size Price Stock Quantity
Oil + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Oil
1 mg In-stock
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
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500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

STF-1623 Related Antibodies

Top Publications Citing Use of Products

View All Phosphodiesterase (PDE) Isoform Specific Products:

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • Biological Activity

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Description

STF-1623 is a highly potent ENPP1 inhibitor with an IC50 of 0.6 nM. STF-1623 inhibits ENPP1, activates tumor-specific STING signaling. STF-1623 blocks breast, pancreatic, colon, and brain cancer progression[1].

IC50 & Target

IC50: 0.6 nM (ENPP1)[1]
Molecular Weight

351.34

Formula

C16H22N3O4P
CAS No.
Appearance

Oil

Color

Light yellow to yellow

SMILES

O=P(O)(O)CCC1CCN(C=2N=CN=C3C(OC)=CC=CC32)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (142.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8462 mL 14.2312 mL 28.4625 mL
5 mM 0.5692 mL 2.8462 mL 5.6925 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.90%

SDS (394 KB)

COA (248 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8462 mL 14.2312 mL 28.4625 mL 71.1561 mL
5 mM 0.5692 mL 2.8462 mL 5.6925 mL 14.2312 mL
10 mM 0.2846 mL 1.4231 mL 2.8462 mL 7.1156 mL
15 mM 0.1897 mL 0.9487 mL 1.8975 mL 4.7437 mL
20 mM 0.1423 mL 0.7116 mL 1.4231 mL 3.5578 mL
25 mM 0.1138 mL 0.5692 mL 1.1385 mL 2.8462 mL
30 mM 0.0949 mL 0.4744 mL 0.9487 mL 2.3719 mL
40 mM 0.0712 mL 0.3558 mL 0.7116 mL 1.7789 mL
50 mM 0.0569 mL 0.2846 mL 0.5692 mL 1.4231 mL
60 mM 0.0474 mL 0.2372 mL 0.4744 mL 1.1859 mL
80 mM 0.0356 mL 0.1779 mL 0.3558 mL 0.8895 mL
100 mM 0.0285 mL 0.1423 mL 0.2846 mL 0.7116 mL
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STF-1623 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STF-16232298391-60-1STF1623STF 1623Phosphodiesterase (PDE)STINGStimulator of Interferon GenesTMEM173MITAERISMPYSbreastpancreaticcolon brain cancerInhibitorinhibitorinhibit

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